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Post mTBI fatigue is associated with abnormal brain functional connectivity

Discussion in 'Other Health News and Research' started by mango, May 6, 2016.

  1. mango

    mango Senior Member

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    Post mTBI fatigue is associated with abnormal brain functional connectivity.

    Nordin LE
    1,2, Möller MC3,4, Julin P3,5, Bartfai A3, Hashim F2,6, Li TQ1,2.

    Author information

    1 Department of Diagnostic Medical Physics, Karolinska University Hospital Huddinge, Stockholm, Sweden.
    2 Department of Clinical Science, Intervention and Technology, Division of Medical Imaging and Technology, Karolinska Institute, Stockholm, Sweden.
    3 Department of Clinical Sciences, Danderyd Hospital, KIDS, Karolinska Institute, Solnavägen 1, 171 77 Solna, Sweden.
    4 Centre for Clinical Research, Sörmland, Uppsala University, Uppsala, Sweden.
    5 Neurological Rehabilitation Clinic, Stora Sköndal Foundation, Stockholm, Sweden.
    6 Department of Radiology, Karolinska University Hospital, Stockholm, Sweden.

    Sci Rep. 2016 Feb 16;6:21183. doi: 10.1038/srep21183.

    Abstract

    This study set out to investigate the behavioral correlates of changes in resting-state functional connectivity before and after performing a 20 minute continuous psychomotor vigilance task (PVT) for patients with chronic post-concussion syndrome. Ten patients in chronic phase after mild traumatic brain injury (mTBI) with persisting symptoms of fatigue and ten matched healthy controls participated in the study. We assessed the participants' fatigue levels and conducted resting-state fMRI before and after a sustained PVT. We evaluated the changes in brain functional connectivity indices in relation to the subject's fatigue behavior using a quantitative data-driven analysis approach. We found that the PVT invoked significant mental fatigue and specific functional connectivity changes in mTBI patients. Furthermore, we found a significant linear correlation between self-reported fatigue and functional connectivity in the thalamus and middle frontal cortex. Our findings indicate that resting-state fMRI measurements may be a useful indicator of performance potential and a marker of fatigue level in the neural attentional system.

    http://www.ncbi.nlm.nih.gov/pubmed/26878885

    (One of the authors, Per Julin, is one of very few ME/CFS specialists in Sweden. He's currently the head of the biomedical ME/CFS center at the Stora Sköndal Neurological Rehabilitation Clinic.)
     
  2. Marco

    Marco Grrrrrrr!

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    Near Cognac, France
    That's interesting. I'm sure he's noticed many similarities between the two syndromes.
     
    mango likes this.

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