Post-exertional malaise as an outcome measure in any ME/CFS trials?

[Tom Kindlon]

A researcher has asked me: does anyone know of any ME/CFS trials that have used a measure of post-exertional malaise as an outcome measure apart from the PACE Trial*

*Aside: which published a yes/no measure (they had used a Likert scale but published a yes/no result)

https://www.facebook.com/hashtag/cfs?source=feed_text&story_id=949779371836855

 

[Tom Kindlon]

I found this:

The Fatigue score was calculated every second week as the mean of the four symptoms: Fatigue, Post-exertional malaise, Need for rest, Daily functioning.

Fluge Ø, Risa K, Lunde S, Alme K, Rekeland IG, Sapkota D, et al. (2015) B-Lymphocyte Depletion in Myalgic Encephalopathy/ Chronic Fatigue Syndrome. An Open-Label Phase II Study with Rituximab Maintenance Treatment. PLoS ONE 10(7): e0129898. doi:10.1371/journal.pone.0129898

 

[Tom Kindlon]

I said they are interested in "trials"; another term is "interventional studies". So studies that measured post-exertional symptoms before and after a treatment of any sort, most likely a questionnaire.

The Rituximab study I found I'm guessing isn't going to be suitable as it is only part of the measure.