I read yesterday where Dr Peterson is finding this an issue with many antiviral responders. I suppose the idea of antivirals/valcyte is that we lower the viral load and hope that our immune system recovers so that when we stop valcyte that our immune system can keep these viruses down. But my self and i think others this doesnt happen, so i think i have relapsed 2 months post valcyte. Dr peterson mentions ampligen with valcyte where the ampligen keeps the immune sytem going post valcyte and thus keeps viruses down. I did use imunovir at one stage on valcyte but stopped as i didnt see alot of improvement but then again i had improved alot that improvement wouldnt have been seen. hind sight i should have stayed on imunovir. Many stay on another antiviral like famvir or valtrex. For me i just dont think famvir is strong enough but i think it does help some. Maybe its worth trying valtrex/famvir combo but i will put that on the back burner for now. So searching for immune supps with some type of science behind it and thats within reach doesnt leave alot of options. Heres a quick list, please add more ? imunovir, cycloferon, LDN, GcMAF, nexavir, inosine, AHCC. Many of the herbs just dont have alot of hard core science and arent recommended by many of the cfs guru's, but i am using an astragalus formula at the moment. So my current plan is that i have ordered more imunovir and started some LDN. I have tried to order cycloferon but seem to have issues there. The MAF would be great but its out of my price range for now. We will see how things pan out on this. I get results soon of some immune testing. My thoughts are to use the immune mods for a month or so and see if things improve and then maybe add the valcyte back for another 6 months and keep the immune mods onboard, which probably means forever. NK function testing i have had in the past should it was crap and i have 2/3 thirds of my tests showing mild neutropenia. Valcyte can worsen this which i think it did with me and the reason for ongoing sinus issues. So valcyte can help viral issues but may cause issues with bacterial issues if neutrophils drop?? I wish i had saved it but i didnt, but i recall dr montoya saying that those who relapsed off valcyte responding again when placed back on valcyte. So its definately on option and maybe need to stay on it longer. It would be interesting to find out if there is some other type of dosing regime to use as a maintenance treatment eg lower doses or some type of alternate dosing which could help reduce any risks of long term side effects. or they could just make a new safer drug, that would be nice??? There was something posted recently where it was more of a hit'm hard and get out quickly type dosing for valcyte. 9 weeks? I think it has merit as i think the gains made on valcyte taper off after a few months, thats my experience anyway. SO maybe then its time to hit the immune mods or some type of low dose maintenance valcyte?? So these are some ideas floating around my head amongst the fog the last few days that i will talk over with my 10min docs appointment soon. I would like to hear peoples opions and from those who have relapsed post valcyte. Maybe things they would do differently? cheers!!!