I think potential Pem- Very interesting. I would like to add my two cents here, for those who are experimenting with this, especially for Wishfull. Does Cuminum act as 1) PEM sheilding (ie PEM prevention) or is it a 2) PEM reducer? (ie, reduces severity and duration after the exertion has already occured.) Example of PEM reducer: CoQ10 does seem to help with PEM severity and duration, and it works well after the exertion, but I've taken loads of it before a social engagement, and I still get PEM afterwards. Example of PEM shielding (prednisone, which I take every Sunday) After I take prednisone (or equiv potency of hydrocortisone), and I do anything afterwards (and I do mean anything) that would normally cause PEM, I never get PEM. BUT... if I take prednisone AFTER the exertion, it does absolutely nothing. From what Wishfull is saying, it sounds like it may be PEM shielding, which is super valuable to me, and If that is the case, I would love to use it as an alternative to prednisone, since corticosteroids have long-term health consequences. I'll be ordering it shortly, but will be curious of other people's experiences with it.