This study showed up a couple of weeks ago, but I'm just getting around to posting it due to the holidays. It got my attention due to the subject is "misfolded proteins". http://www.sciencedaily.com/releases/2013/12/131209181101.htm I know Dr. Baraniuk's studies have noted the presence of misfolded proteins in CSF of ME/CFS patients. The attached study references them under the "Amyloid Proteins:" section in this study. http://phoenixrising.me/research-2/...roteins-on-the-brain-spinal-tapping-for-mecfs There was another study recently posted here that referenced "misfolded proteins", but I can't remember which one or who the author was. Misfolded proteins seem to be prevalent in many diseases, but were never a target for treatment. This could possibly change in the very near future as this has got to get the attention of the pharmaceutical companies now. Could a phase or step in the creation or effects of misfolded proteins cause a significant change in ME/CFS at the approximately 3 year point in the disease?