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Possible cause of IBS revealed

Discussion in 'Other Health News and Research' started by guest, Sep 11, 2010.

  1. guest

    guest Guest

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    Kofi posted some very interesting articles on the lef group. I tried to highlight the important parts:

    The above story is reprinted (with editorial adaptations by ScienceDaily
    staff) from materials provided by Society for General Microbiology, via
    EurekAlert!, a service of AAAS.

    A possible cause of irritable bowel syndrome has been traced to a small
    piece of RNA that blocks a substance protecting the colon membrane,

    leading to hostile conditions that can produce diarrhea, bloating and
    chronic abdominal pain; this RNA segment sends signals that stop the
    activity of the gene that produces glutamine; a shortage of glutamine in
    the gut is linked to the seepage of toxins and bacteria through the
    intestinal wall, irritating nerves and creating disease symptoms;
    trying
    to generate glutamine in the disordered bowel by silencing this RNA
    segment could treat the diarrhea-predominant type of IBS; this form is
    characterized by diarrhea and bloating as well as chronic abdominal pain
    that is difficult to treat; a third of IBS patients have the
    diarrhea-predominant type, another third experience consistent
    constipation, and the rest experience alternating bouts of diarrhea and
    constipation; in human tissue samples, the presence of this small piece
    of RNA was associated with reduced activity by the gene that produces
    glutamine. Lower levels of glutamine were seen only in tissue samples
    from patients with the diarrhea-predominant type of IBS; a group of
    these patients also had a condition called increased intestinal
    permeability, which allows toxins and bacteria into the colon that
    typically can't get in. The resulting irritation to nerves in the colon
    is believed to contribute to diarrhea and abdominal pain; the glutamine
    deficiency may be connected to the increased intestinal permeability,
    which dramatically increases the likelihood that diarrhea-predominant
    IBS symptoms will follow; manipulating microRNA-29a (miRNA-29a) has
    potential as a novel treatment for IBS; for some patients, the pain
    responds only to escalating doses of narcotics or tricyclic
    antidepressants; microRNA-29a levels were four times higher in the
    tissues of IBS patients with increased intestinal permeability than were
    levels seen in IBS patients with normal intestinal permeability
    conditions and in participants with no bowel disease; when the
    microRNA-29a levels were driven up, the function of the gene that
    produces glutamine was prevented and intestinal membrane permeability
    increased, as well. When the microRNA-29a was artificially silenced,
    gene function was active, glutamine was produced and the intestinal
    membrane permeability was closer to normal; there may be other target
    genes involved


    <http://www.sciencedaily.com/releases/2010/08/100802110825.htm>

    MicroRNA-29a regulates intestinal membrane permeability in patients with
    irritable bowel syndrome
    ; The molecular mechanisms underlying the
    pathophysiology of irritable bowel syndrome (IBS) are poorly understood.
    One mechanism may involve increased intestinal permeability that is
    reversed with glutamine supplementation. Our goal was to evaluate the
    expression of glutamine synthetase and its complementary miRNA in blood
    microvesicles and gut tissues of IBS patients with increased intestinal
    membrane permeability. METHODS: We evaluated 19 diarrhoea-predominant
    IBS patients and 10 controls for intestinal membrane permeability using
    the lactulose/mannitol method. miRNA expression was evaluated in blood
    microvesicles and gut tissue. To further confirm the relationship
    between miRNA and glutamine synthetase expression, cell culture
    experiments were conducted. Glutamine synthetase was also evaluated in
    the gut tissues of patients; A subset of patients with IBS (8/19, 42%)
    had increased intestinal membrane permeability and decreased glutamine
    synthetase expression compared to patients with IBS normal membrane
    permeability, and to controls. Expression of miR-29a was increased in
    blood microvesicles, small bowel and colon tissues of IBS patients with
    increased intestinal membrane permeability. Increased intestinal
    permeability was modulated by miR-29a which has a complementary site in
    the 3'-UTR of the GLUL gene; GLUL regulates intestinal membrane
    permeability and miR-29a regulates both GLUL and intestinal membrane
    permeability. The data suggests that miR-29a effects on intestinal
    membrane permeability may be due to its regulation of GLUL. Targeting
    this signalling pathway could lead to a new therapeutic approach to the
    treatment of patients with IBS, especially because small molecules that
    mimic or inhibit miRNA-based mechanisms are readily available
    [PMID
    19951903]
     
  2. illsince1977

    illsince1977 A shadow of my former self

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    MicroRNA seems to be the latest thing. I heard it referenced in the latest TWIV Podcast and on a Tech Nation podcast from April 15, 2010. I got the impression from TWIV that since microRNA is so small they didn't know it was there until (in scientific timelines) recently. It may become the basis for many therapeutics. If it is regulates gene expression, this makes sense.
     
  3. guest

    guest Guest

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    Medicine seems an exploding universe and I'm really scared that the majority of the actual scientific establishment is not able to cope with it.
     
  4. Deatheye

    Deatheye Senior Member

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  5. illsince1977

    illsince1977 A shadow of my former self

    Messages:
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  6. revita

    revita [banned as spam]

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    Wow, what a great information you have here. RNA was a great subject that was talked this past few months. I' have already heard some information about this but this is much better than those. Thanks
     

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