http://www.kutv.com/news/top-stories/stories/vid_8971.shtml KUTV) A scientific breakthrough that could change the lives of those suffering from Lyme disease and rheumatoid arthritis as researchers at the University of Utah's Department of Pathology identifies a gene deficiency that makes individuals susceptible to developing severe inflammatory arthritis. I'm sorry, i don't know how to embed the video. If your'e science minded you may prefer to read the Journal of Clinical Investigation article. Lysosomal β-glucuronidase regulates Lyme and rheumatoid arthritis severity http://www.jci.org/articles/view/72339 C3H mice expressing WT Gusb as a transgene were protected from severe Lyme arthritis. A known GUSB function is the prevention of lysosomal accumulation of glycosaminoglycans (GAGs). Development of Lyme and rheumatoid arthritis in Gusbh-expressing mice was associated with heightened accumulation of GAGs in joint tissue. We propose that GUSB modulates arthritis pathogenesis by preventing accumulation of proinflammatory GAGs within inflamed joint tissue, a trait that may be shared by other lysosomal exoglycosidases.