I was thinking recently as to what in the world started my current fatigue issue. For one, I had a massive mold inhalation a few years ago and was very sick. I'll call that Year one--Mold. I started to recover that Fall, slowly Year Two--good energy, but problems creeping up by the Fall. i.e. though the mold problem of the previous year seemed totally gone, I was under a lot of stress during that very active year and was dealing with it wrong. So I was seeing problems here or there cropping up by the Fall, even with good energy.... Year Three--good energy but growing problems, heavy metal detox, OAT testing. I still had good energy, but by the fourth month of this year, after doing blood and hair testing, found myself with high heavy metals, and especially high copper. Bingo. I started a detox, and by the third week, massive debilitating fatigue hit and this is where I realized something was very wrong. So I look back at this and wonder: did the mold back in Year One start damaging my mito, or was it the rising copper that had started in Year Two and was now even higher in Year Three?? I also did an OAT (Organic Acids Test) and saw many mito problems which I started to treat. Year three ended up with SIBO after the miserable detox, then candida from over-treatment of the SIBO, which took me five months to fully get rid of (into Year Four). Year Four--another copper detox, easy crashing, a second OAT confirming my mito were a mess This was the first time my energy levels were clearly kaput from the beginning. It took me into late Spring to fully get rid of the candida from late Year Three...but then I went into another copper detox from taking high doses of phospholipids (had read it heals mito--didn't expect it to cause a detox). Absolute fatigue misery all over again. And again, another OAT confirmed that my mito were in trouble, plus I need higher CoQ10. And it was the fall of this year I found out via testing that maybe the mold has never been fully gone, as I'm part of 24% of the population which has genes which cause me to need extra help, plus I found out I had brain inflammation! Mold!! Started treatment to remove the mold by December. Also saw methylation problems starting at the end of this year--rising B12, rising iron. Year Five (this year)--low energy levels, easy crashing So here I am today: 1) I'm now working to improve my methylation with higher doses of folate (and it's working) and sometimes need extra potassium due to the increased methylation improvement. 2) I continue treating what two OATS from previous years have revealed with targeted supplements. I still go back to my OAT results and discover something new! 3) I've raised some of my supplements to treat borderline low results on the Spectracell test, like B5, B6, Folate, Biotin, Manganese, and Chromium, 4) Awaiting the results of the Amino Acids test and will treat accordingly. 5) Removing mold with cholestyramine, albeit can't take it four times a day due to other things I have to take Bottom line: I don't know if the MOLD from Year One was the impetus, or the HIGH COPPER which was going up at the end of Year Two, and especially in years Three and Four, or both. But they seem to have played a big role. I do see others make guesses as to what started their CFS or ME: flu, EBV, other viruses, cancer treatment, stress, antibiotics, diseases, to name a few. I also see that certain stressors can make worse what was already there, such as with genetics....I think this may be the case for me, as I never had top-notch energy like some do---I was just average before all this hit. So all I can do is be hopeful that all the things I'm treating just might turn me around....in time. We'll see.