Okay, I have a very specific problem that no doctor has been able to help with, and I have not been able to help myself with, so I'll take a chance here. It's embarrassing, but it's problematic enough that I don't really care anymore. It's quite a simple problem - when going to sleep, and only when going to sleep, I have to pee frequently, every 2-10 minutes, sometimes for half hour to an hour. This can be 10x a night. The urgency is high, and it feels like my body is trying to expel all fluid in order to sleep. My ADH levels are normal during the day, and at morning Desmopressin reduces quantity, but not the problem, duration or urgency The amount of liquid I drink at night before bed can be quite small, maybe an ounce or 2 and yet I will put far, far more out than what i drank in the previous 4-6 hours I do not wake up to pee, bed wet I do have POTS, the problem existed before I was on any medication for it (midodrine) and medication doesn't seem to help Seems to be a problem regardless what time I try to sleep, and is only initiated by the act of going to sleep. Elevating bed, and standing upright don't seem to matter as long as I'm my body is preparing to sleep I would say I have polyuria during the day, in part driven by excessive thirst & POTS, however it is nothing like before bed. I do not have sleep anxiety, and I do not worry about the problem in anticipation of it. It's an incredibly depressing problem, and internet searches have shown a few people looking for advice and not finding answers (example 1, example 2). Any advice appreciated.