What KDM study? AFAIK, a substantial proportion of us have dysbiosis. I reacted badly to Co-Q10 too = hypo. Maybe that is because my blood glucose is well-controlled, so I clearly don't have an insulin problem, at least since being on my leaky-gut diet and supplements (don't know what it was like before). Many of us consider that the leaky-gut diet and supplements is the best way to fix dysbiosis, and I certainly have vastly better digestion since starting it, suggesting that I have fixed the dysbiosis. Gut flora are largely determined by diet. I don't know whether or how d-ribose could fix the gut or immune system, and my immune system doesn't seem to need boosting, as I almost never get colds or flu, like many of us here. This is not email. It is a forum for discussing all issues to do with ME. Coffee-table?? I can bear a hell of a lot, but if an adverse effect is severe I take that as a warning.