I have nocturia - right now it's fairly calmed down and I only go once or twice at night, but typically it's large volume - I lose 5# overnight sometimes. I have been tested for Addisons & diabetes insipidus (both negative). I have lots of trouble with electrolyte balance & have severe orthostatic hypotension at times. The ONLY supplement that has made a big difference is alpha lipoic acid. I have no idea why, but sometimes when I am taking that I don't even wake up once to go. Florinef did not make a difference, heavy salt loading does not help. I have been using mB12 for 16 months now and it does not seem to make a difference. I think ALA may help sugar get into my cells rather than being urinated out and that reduces nocturia. I am not diabetic, but I will occasionally have a fasting sugar in the mid 90's. I also was having a lot of problems with adrenaline release at 4 a.m. w/ glycogenesis - I tend to think it's all related in my case. In any event, it's all improved with ALA (which I am off of for now on a sulfur exclusion test diet).