@Freddd Thanks so much for your detailed information! I am a newbie looking to embark on methylation unblocking. Just to clarify: what are the core "deadlock quartet" supplements? My current understanding of what's initially required (in simplified terms, I've noted brands/amounts above) is this: 1) Remove folate/glutathione from diet. Add back in when comfortable with the progress of the protocol. 2) Low dose B-Complex (1, 2 &3) without folic, folinic acid and CyCbl. 3) Sufficient diet/supplementation of: Vit A, C, D, E, magnesium, zinc, calcium, selenium, chromium, trace minerals, lecithin, and Omega 3. 4) MeCbl 5) AdoCbl 6) L-methylfolate 7) Potassium 8) L-Carnitine Fumarate A few questions: a) is this correct? b) is there anything necessary/advisable to take after 8? c) are Bananas a sufficient source of potassium, as opposed to supplementation? d) any particular brands in 2 & 3 that are advisable? any that should be avoided? e) i plan to start on small doses of 4, 5, 6, and 8. But what are the maximum amounts I should be working up to? f) if I notice an increase in symptoms during the early stages of the protocol, this is to be expected and I should continue taking the supplements? g) if there is no increase in symptoms during the early stages than I can increase the dosages? h) if after increasing the dosages to the maximum there is still no increase in symptoms, nor any noticeable improvement, then I probably do not need to continue the protocol? I really appreciate your work. Thanks so much!