The 12th Invest in ME Conference, Part 1
OverTheHills presents the first article in a series of three about the recent 12th Invest In ME international Conference (IIMEC12) in London.
Discuss the article on the Forums.

Poll for maternal haplogroup as possible indicator for ME/CFS phenotype

Discussion in 'Genetic Testing and SNPs' started by nandixon, Apr 15, 2015.

?

What is your maternal haplogroup and phenotype with respect to fatigue or exhaustion?

  1. My haplogroup is "H" and I suffer continual fatigue or exhaustion.

    37.8%
  2. My haplogroup is "H" and I suffer abnormal fatigue or exhaustion but only after exertion.

    10.8%
  3. My haplogroup is "H" and fatigue or exhaustion is not a significant issue.

    0 vote(s)
    0.0%
  4. My haplogroup is "J" and I suffer continual fatigue or exhaustion.

    10.8%
  5. My haplogroup is "J" and I suffer abnormal fatigue or exhaustion but only after exertion.

    2.7%
  6. My haplogroup is "J" and fatigue or exhaustion is not a significant issue.

    0 vote(s)
    0.0%
  7. My haplogroup is not "H" or "J" and I suffer continual fatigue or exhaustion.

    32.4%
  8. My haplogroup is not "H" or "J" and I suffer abnormal fatigue or exhaustion but only after exertion.

    5.4%
  9. My haplogroup is not "H" or "J" and fatigue or exhaustion is not a significant issue.

    0 vote(s)
    0.0%
  1. nandixon

    nandixon Senior Member

    Messages:
    785
    Likes:
    1,889
    I thought it would be interesting to see if a person's mitochondrial DNA/maternal haplogroup has an effect on ME/CFS "phenotype" (characteristic symptoms) after learning that the mtDNA for the J haplogroup has been found to consistently produce less ATP than that of the H haplogroup, all else being equal. (See this post/thread here, and thanks to @Eeyore.)

    To answer this poll, if you've done 23andMe please find the first letter of the haplogroup that denotes your maternal line from the following link (you'll need to login first):

    https://www.23andme.com/you/haplogroup/maternal/

    For example, I'm "J1c" so I belong to the J haplogroup.

    You may also have found your mtDNA/maternal haplogroup from other testing services, such as Family Tree DNA, etc.

    If your maternal haplogroup is neither H nor J, you're no less important but the differences in ATP production are perhaps not so clear as they are between H and J, so I've combined the remaining haplogroups in the choices for their answers.

    If you don't know your maternal haplogroup please do not answer this poll.

    Thanks for participating!
     
    oceiv, ahmo and Valentijn like this.
  2. SOC

    SOC

    Messages:
    7,802
    Likes:
    16,454
    @nandixon,
    I had years of continual exhaustion, but now that I'm pacing well and getting a number of good treatments, I only have abnormal exhaustion if I go outside my energy envelope. So, continual exhaustion is a feature of my illness overall, but proper management has it under good control. Which category would you want me to put myself in: continual exhaustion, or exhaustion after exertion?
     
  3. nandixon

    nandixon Senior Member

    Messages:
    785
    Likes:
    1,889
    @SOC, I would say in the continual exhaustion category since it seems that would be your body's "natural" response to this illness if you hadn't been fortunate enough to have found helpful treatments and pacing. Thanks!
     
    SOC likes this.
  4. ahmo

    ahmo Senior Member

    Messages:
    4,318
    Likes:
    6,424
    Northcoast NSW, Australia
    Oh...I clicked the 2nd, exhaustion after exertion. I thought about it. I'm less exhausted than I was before methylation protocol. But I noticed today that I seem to be surprised over and over again by how little activity I actually can do. And I'm now very careful about not over-doing. So maybe I belong in Category 1.:confused:
     
    nandixon likes this.
  5. WoolPippi

    WoolPippi Senior Member

    Messages:
    504
    Likes:
    1,354
    Netherlands
    You can change your vote if you wish to.

    I considered voting the 2nd too because I can mostly identify what makes me exhausted. Realizing I was about to label "sleeping" to be "exertion" because I wake up exhausted I then voted the 1st category :D
     
    Last edited: May 11, 2015
    ahmo and nandixon like this.
  6. ahmo

    ahmo Senior Member

    Messages:
    4,318
    Likes:
    6,424
    Northcoast NSW, Australia
    @WoolPippi Done!:thumbsup:

    :rofl::hug:
     
    ukxmrv and WoolPippi like this.
  7. sue1234

    sue1234

    Messages:
    8
    Likes:
    3
    What about "T" maternal haplotype?
     
    nandixon likes this.
  8. nandixon

    nandixon Senior Member

    Messages:
    785
    Likes:
    1,889
    You would choose one of the "My haplogroup is not "H" or "J" and..." options. Thanks!
     
  9. lnester7

    lnester7 Seven

    Messages:
    2,270
    Likes:
    3,174
    USA
  10. sue1234

    sue1234

    Messages:
    8
    Likes:
    3
    @nandixon , I'm so embarrassed! I didn't read the choices close enough to see the "not" choices.
     
    nandixon likes this.
  11. ukxmrv

    ukxmrv Senior Member

    Messages:
    4,241
    Likes:
    4,119
    London
    Hi @nandixon

    Here's a vaguely similar poll that I set up. Did add another post when the latest news came through (about H)

    http://forums.phoenixrising.me/index.php?threads/what-is-your-maternal-haplogroup.24510/#post-592068

    I have voted as a J and continual exhaustion but neither option was entirely right. Have ME as per Ramsay and he reported that may of his patients were not TATT but had a daily rhythm and sometimes felt the exhaustion/weakness etc lift a bit. I do always get bad PEM malaise though.

    Answered yes to continual because I never feel completely right or normal. Just varying degrees of awfulness during the day.
     
    nandixon likes this.
  12. Hutan

    Hutan Senior Member

    Messages:
    1,006
    Likes:
    5,567
    New Zealand
    @nandixon My son and I, both with ME, are both J1c2.
     
    nandixon likes this.
  13. Critterina

    Critterina Senior Member

    Messages:
    1,200
    Likes:
    691
    Arizona, USA
    Maternal haplogroup D4e1 and no CFS or ME. D is not a choice, so I'm not taking the poll. Fatigue and exhaustion were not an issue until adrenal insufficiency and histamine intolerance took their toll. I have energy now but have not recovered my fitness level.
     
    nandixon likes this.
  14. nandixon

    nandixon Senior Member

    Messages:
    785
    Likes:
    1,889
    Thanks @Critterina. People with the D haplogroup would fall into one of the three "not H or J" options, but the poll is just for people with ME/CFS.
     
  15. Critterina

    Critterina Senior Member

    Messages:
    1,200
    Likes:
    691
    Arizona, USA
    Sorry, it wasn't clear that the poll was JUST for people with ME/CFS. If you decide your science would be better with a control group, there are plenty of us here.
     
    Valentijn likes this.
  16. nandixon

    nandixon Senior Member

    Messages:
    785
    Likes:
    1,889
    @Critterina, sorry that it wasn't clear and I hope you don't end up with a ME/CFS diagnosis. (It's too late for me to be able to edit anything to make it more clear.)
     
  17. Critterina

    Critterina Senior Member

    Messages:
    1,200
    Likes:
    691
    Arizona, USA
    Oh, that's fine. No problem. And thanks for your good wishes. I think that although I share a lot of SNPs with the ME/CFS people, (also with the bipolar/schizophrenia people), that it's very unlikely that I'll get that diagnosis.

    I'm very thankful for this forum, as it has helped me exceedingly in trying to figure out what illnesses took me down and to recover. I've also learned language to talk about symptoms, some that have been with me since birth and I just thought were normal. Meanwhile I've gained sympathy with doctors in distinguishing symptoms from diagnoses, and learned that there are some standard ways of describing certain feelings (and that saying "buzzy arms and legs" will get you further than saying "champagne bubbles in my arms and legs" - although I thought the second one said it perfectly.)
     
    whodathunkit and merylg like this.
  18. PatJ

    PatJ far and free I gaze

    Messages:
    1,730
    Likes:
    4,717
    Canada
    Mine is V. From some limited brain-fogged reading it seems that it's quite close to H, but 23andme just says "V a subset of R0". I voted for Not H or J with continual exhaustion, although it's more like I have a very small energy envelope. House-bound and mostly bed-bound due to OI and the small energy envelope.
     
    merylg and nandixon like this.
  19. whodathunkit

    whodathunkit Senior Member

    Messages:
    1,158
    Likes:
    1,469
    Well said, Critterina! I second this, wholeheartedly! I don't know where I'd be today without PR.
     
  20. whodathunkit

    whodathunkit Senior Member

    Messages:
    1,158
    Likes:
    1,469
    Ooops, I voted. Didn't realize you had to have an official diagnosis until reading through comments.

    I voted for my pre-PR state of continual fatigue, haplogroup H. @nandixon, will you please delete my vote?
     

See more popular forum discussions.

Share This Page