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Sulfites are a big issue. If you are experiencing CFS/FMS symptoms, you should be aware of how they work and how they can affect you.
How Sulfites can Hurt You
Sulfites can hurt you if your protective Sulfite Oxidase enzyme (a chemical that converts one chemical to another chemical) is low. Sulfite Oxidase converts sulfites to sulfates, which are not
harmful. If your Sulfite Oxidase enzyme is down, the sulfites will swim around your blood and inhibit important enzymes such as Tyrosinase, polyphenoloxidase, and ascorbate oxidase. This can result in the impairment of the synthesis of Dopamine and the conversion of Dopamine to Noradrenaline, which can lead to neurological fatigue. Sulfites can inhibit 90% of lung ATP energy production, can impair liver cell ATP energy production, and can deplete glutathione (chemical that helps the liver filter the blood and helps protect cell enzymes from damage). Anything that reduces your production of ATP energy can cause fatigue, since low levels of energy are synonymous with fatigue.
Things that can inhibit your protective Sulfite Oxidase enzyme
Things that can impair the protective sulfite oxidase are as follows: heavy metal molecules such as lead and mercury, Sulfa-drugs (e.g. a class of drugs within the sulfa group that can impair pterin synthesis, such as asthmatic inhalants and many antibiotics), molybdenum deficiency, proto-IX-porphyria (enzyme that makes blood inhibited), inherited genetic damage encoding of the SO-enzyme, severe B12-vitamin deficiency, and arrays of So2/SO3-group containing drugs including DMPS (an Rx chelation drug)."/quote]
Hi Radio,
great job on the research .... If you go a bit further Sulfite Oxidase enzyme deficiency is a very rare condition and the consequences are way more severe than CFS
"Sulfite oxidase deficiency is an inborn error of the metabolism of sulfated amino acids. Individuals affected with sulfite oxidase deficiency most commonly present in the neonatal period with intractable seizures, characteristic dysmorphic features, and profound mental retardation."
You will probably also find that the excess of hydrogen sulphide in the blood is also linked to an overgrowth of hydrogen sulphide producing bacteria in the gut (disbyosis) .... so to finish off your research fully, consider putting that into the equation ....
Just something to think about .....
Here is a good article that fills in some of your gaps ....
http://www.medscape.com/viewarticle/732378_10
Cheers.
Low sulfate can occur for a variety of reasons. Some gut infections (bacteria/yeast) can produce large amounts of phenols....which may overload the PST enzyme....causing a shortage of available sulfate.
Hi Radio
You'll have to excuse my question here because it stems from my lack of biochemistry knowledge, so maybe you can help answer a question.
In one of Dr. Seneff's podcasts I listened to, she mentioned that Resveratrol, Curcumin, polyphenols, and flavonoids help with sulfate transport within the body.
If this is a good thing, then what is the difference between polyphenols and phenols, besides their molecular makeup? In your post above it states that excess phenols is not a good thing, so hence my question.
Can't we just eat more sulfur foods?
Radio, l was admitted into hospital with mercury poisoning at five months of age - Pinks Disease, and then played with it at age 9 or thereabouts with lifelong health problems but my kidneys seem to be okay. Urine sulphate is low so do you know what that implies?
@Radio
Thanks. You are right about salicylates and I have s adjucts on my genes and have cut back with diet and topical. The thing I do not understand is why I am low in urine sulphate , so it is not due to sulphate wasting where urine levels would be high like with children with autism. I am doing magnesium sulphate foot baths atm and think that it helps. Thanks for the links and the explanation about p5p.