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Plos One: Reduced Cardiac Vagal Modulation Impacts on CFS

Discussion in 'Latest ME/CFS Research' started by Firestormm, Dec 16, 2012.

  1. Firestormm

    Firestormm Guest

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    I meant to post this the other day and forgot. Sorry. Comments from Charles Shepherd follow accompanied by a link to Julia Newton's latest work, and a video of her recent presentation.

    Charles Shepherd ME Association Facebook 15 December 2012:

    Julia Newton and POTS: http://forums.phoenixrising.me/inde...-characteristics-of-novel-subgroup-cfs.20807/

    Julia Newton presentation and overview of NICE sponsored research: November 2012: http://forums.phoenixrising.me/inde...-characteristics-of-novel-subgroup-cfs.20807/
     
    anne_likes_red likes this.
  2. Marco

    Marco Old blackguard

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    Yes - very interesting. The finding of cognitive accuracy but reduced processing speed in ME/CFS is an old one and reduced heart rate variability is a common finding in MDD and ADHD to name a few (which doesn't concern me).

    The question is, how the two are connected and what it implies for ME/CFS the condition.

    Given the known associations of reduced heart rate variability and cognitive dysregulation could researchers not speculate as to what they believe might be going on or does it just fall under 'interesting - there you go!'?.
     
    anne_likes_red, justy and Firestormm like this.
  3. Firestormm

    Firestormm Guest

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    I'm not even sure that Newton associates autonomic dysfunction with cognitive difficulties, Marco. I can't remember (lol) whether this came up in her presentation or not. Am transcribing - so will find out in due course and post accordingly.

    The more these studies acknowledge the difficulties though the greater the weight behind our anecdotal evidence I guess. Though I agree some answers or direction would be nice.
     
  4. Marco

    Marco Old blackguard

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    Charles Shepherd's commentary does though which, if he's suggesting that ANS dysfunction is causing cognitive difficulties, is not a safe assumption to make. Both could be symptoms of the underlying root cause.

    It would be interesting if Julia Newton considers them causally linked or indicative of something else.
     
    alex3619 and Firestormm like this.
  5. lnester7

    lnester7 Seven

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    In my case I am 100% sure that the cognitive issues are tied to my autonomic dysfunction. I can provoke my episodes (I am doing OI training) and I note what symptoms go with it: Dizziness, Head buzz and Fog, Nausea, numbness, tingling.... Also when you get the tilt table test, pay attention to what your feeling, it will help you isolate the OI issues.

    Also, If I lay down, After a while I can think better.
     
  6. Firestormm

    Firestormm Guest

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    Very interesting. Thanks Inester. I'm not sure if I remember Newton saying that the 'tilt table' was the preferred or indeed only means to determine autonomic dysfunction. I'm rather a novice when it comes to all of this. Will know more when I finish my transcript I suppose. But I do seem to recollect that performing the 'tilt table test' is not something all physicians are willing to do. Is there a more acceptable alternative? Or are they (we) waiting for the science to point the way?
     
  7. mellster

    mellster Marco

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    Good find! While mine was very mild, it def matched the slow response/HRV and delayed recovery at that time which leads me to continue to believe that the heart is structurally sound in most patients, but it is simply not well regulated by the nervous/metabolic/hormonal system.
     
  8. ramakentesh

    ramakentesh Senior Member

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    Vagal/parasympathetic withdrawal has been mentioned previously. mestinon may help?
     

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