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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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Please help

Messages
4
HI friends,

I don't know what to do anymore cause I'm so sick and have been for a very long time. This is my first time posting but I read here a lot. I have CSF, a bunch of virus's, connective disease issue,mental problems which I am on medication for,Lyme disease. I feel as my body doesn't detox properly and that might have a lot to do with my problems. I feel like I can't, and don't know if I want to go on anymore.

Can you guys help me by looking at my worst snp's and help me determine how to help myself. Also, I just found out I'm in menopause and planing on trying bioidentical hormones for that. I react to everything I try, even supplements cause severe anxiety.
Please help me if you can. I'm desperate! Thank you. Here are some of my snp's.

BHMT-08 het, CBS-rs2851391- het, CBS-A360A- het, COMTH62H-++,COMTV158M-++,
COMTP199P-+\-,MTHFR-A1298c+\-, MTHFR C677T+\-,MTHFR P39P+\-, 5 more MTHFR's but I don't know if they're important. MAOA +\+, MTHFD1+\+, MTRR K350A+\-, VDRTag+\-

I really don't know if the other's are important so I'll end it there. Thank you for reading all this!
 
Last edited by a moderator:
Messages
4
I forgot to ask. Do most with COMT take B12 and Methylfolate, with no problem? I believe I'm Overmethylated due to a low histamine blood test. Should I avoid methyl's? I get overstimulated from them. Thanks again
 

taniaaust1

Senior Member
Messages
13,054
Location
Sth Australia
I can only speak for myself, I have a double copy of the COMT mutation but take methyl B12 and active folate (folinic acid) for my double copy of the worst MTHFR mutation. In my own case they help.