Hello everyone my name is Pat and this might me my first post on this forum but I have been a long time lurker. It was this forum that motivated me to take a dna test from 23andme so that i can trully understand my metabolic problems and not just speculate based of off symptoms. I show classic undermethylator and pyrolouric symptoms. I have already addresses my pyroluria symptoms with a zinc/vitb 6 based supplement regimen. I could help anyone in the area of pyroluria just PM me. (vitb6/zinc isn't the only thing in my regimen). If you want to check if you have pyroluria the SNP responsible is Rs4654748 on gene NBPF3; positive for any T base pairs. I uploaded my results from genetic genie so all gene mutation are easy to interpret. My results revealed that I have big problems in the BHMT pathway and MAO-A. I want to focus on addressing the bhmt deficits considering not much can be done to help the MAO-A deficits (correct me if i'm wrong). From what I have researched so far theyre is a slew of vitamin supplements and rna nucleotide supplements I can consume to dampen the undermethylator symptoms and facilitate the bhmt pathway. First off, the vitamins supplements that ive read that could potentially help include TMG, DMG, NADH, METHIONINE/SAMe. However, im a little skeptical of these supplements, specifically TMG. Around 3 months ago, prior to me taking the dna test, I started dosing about 500 mg of TMG every morning and it resulted in an alleviation of my undermethylator symptoms while simultaneously causing weight gain and excessive urination. I understand why the TMG cured the methylation symptoms. But I still don't understand the weight gain and excessive urination. I have a hypothesis that the weight gain and excessive urination was caused by the TMG remethylating too much homocysteine. Therefore, not enough homocysteine was being metabolized and entering the CBS pathway causing the problems. If anyone could shed any light on the wieght gain and excessive urintation that would be great. I want to take TMG/DMG/NADH/METHIONINE supplements but I worry about them causing adverse reactions in the concentration of BHMT. For example, If one takes DMG, bhmt is down regulated resulting in a reduction of the endogenous BHMT production/TMG metabolism. I think if one takes these supplements they should balance them with the compounds present before and after the BHMT enzyme so one will have higher levels of TMG/DMG/METHIONINE and no reduction in BHMT caused by down regulation due too excess DMG. What does everyone think on this? Secondly, as for the RNA nucleotide supplements I am very clueless. I don't understand they're mechanism of action, side effects, or basically anything. If anyone could add they're anecdotal report with they're experience and maybe some links to websites with information i would greatly appreciate it!!!!! In advance thanks for any help and I will hopefully help you all. Ive been researching metabolism for some time now and have acquired information that could be useful on this forum. Ask any questions!