Hi All, I have only posted once here, regarding what I thought was a strange methylation experience. In summary, I had a great reaction (lots of energy, metter mood, more confidence ) to a Coenzymated B Complex (though later I noticed that it did contain some Folic Acid). I increased the dose and added Mb12, Adb12 and LCF and in a few weeks had next to no energy. Well I have finally got my 23andme snps back and they perhaps, at least partially answer the above experience. I only have a very basic grasp of what is going on here. But I seem not to have much of an issue metabolising Folic Acid and B12 (although I am hetro for MTHFR A1298C). My main concern is CBS and BHMT conspiring against me. I guess when I increased Metafolin and MB12 I was converting more and more Homocysteine into cystathionine down the trans-sulfurtion pathway? In doing so creating more Ammonia and perhaps depleting BH4. COMT doesn't look good. It again I think conspires against me along with MAO. This might help to explain my persistent mood issues. COMT in isolation would suggest high Dopamine as it is involved with the breakdown of this neurotransmitter amongst others. However, I have extremely low drive and motivation, this would suggest low Dopamine. I guess the ammonia created by my CBS +/- snp is using up BH4 so I am perhaps not making enough Dopamine in the first place (i.e. COMT doesn't have enough Dopamine to break down even if it wasn't mutated!). I believe I should tackle the CBS mutation first. I am confused here as I don't seem to have a problem with sulfur, I'm ok with onions, garlic and NAC. I feel good on taurine, I do well on B6 and P-5-P. The only thing I didn't seem to react well to MSM. Anyway, I might have all this wrong and I would appreciate someone with more knowledge and a clearer brain to have a look and make comment. Many thanks in advance for any help you can provide.