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Plasma cells research

Discussion in 'General ME/CFS Discussion' started by Marky90, Feb 11, 2016.

  1. Marky90

    Marky90 Science breeds knowledge, opinion breeds ignorance

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    Hi guys

    Recently i became part of a norwegian grant organization, which assess research proposals, and if considered good; help fund the study.

    At the moment we are starting up a study on intravenous gammaglobulins for ME/CFS.

    Another topic I feel is important to explore, is the lifeline of plasma cells.
    I have tried to find research on this, but with no luck so far.
    As they possibly play an important role in the pathogenesis (rituximab responses might indicate so), would it not be of interest to explore further what mechanisms it is that keeps these cells alive, where they usually are, and if anything is different with the former when possible autoimmune processes are going on.

    @Jonathan Edwards What do immunology know of this? do you find this a topic worth exploring? My layman gut feeling is that this is quite hard to research properly?

    Wanted to check here before i propose this kind of research to the organization.
     
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  2. Billt

    Billt Senior Member

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    Would be very interested in how this study goes ..
     
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  3. jimells

    jimells Senior Member

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    Is your organization looking for research proposals to fund, or is your group picking a topic, and then you will look for an interested researcher? If the latter, there is so much to study, good luck trying to figure out the highest priority.
     
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  4. Marky90

    Marky90 Science breeds knowledge, opinion breeds ignorance

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    Currently- both:)
     
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  5. Marky90

    Marky90 Science breeds knowledge, opinion breeds ignorance

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    We also have a board of doctors who evaluate research proposals, some of them involved in the rtx-trials.
     
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  6. BurnA

    BurnA Senior Member

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    Markey90,
    It's great to hear you are involved in this and that it exists.
    May I ask if there is funding already in place for any of this or would each study require a full round of funding. And if so, would you be confident the funding can be got ?
    Thanks.
     
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  7. Marky90

    Marky90 Science breeds knowledge, opinion breeds ignorance

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    Hey BurnA,

    We got some funds to get the proposal stage going, with regards to IVIG. However it will require a full round of funding, yes, but we are certain to get it. This is the same group that made the funding of rtx phase 3 possible, and also a ongoing gene-project at Haukeland university hospital.

    We try to become bigger so that we always have the money to start a promising project instantly.
     
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  8. BurnA

    BurnA Senior Member

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    :thumbsup:
     
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  9. jimells

    jimells Senior Member

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    @Marky90 the research program in Norway makes NIH look like a bunch of amateurs. Maybe your group could invite Dr Collins to Norway so he could learn how it is done, although trying to teach NIH anything about our illness is probably a fool's errand.
     
    Billt, sarah darwins and Marky90 like this.

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