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Plant Extract Honokiol - For Inflammatory Brain Damage ?

Discussion in 'Antivirals, Antibiotics and Immune Modulators' started by Wayne, Jan 15, 2013.

  1. Wayne

    Wayne Senior Member

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    I found this article to be very interesting. -- Sounds like it could be a promising therapy for pw/CFS with brain inflammation symptoms. Definition of Honokiol: A plant extract derived from the bark of the Magnolia tree, which apparently has been used for thousands of years in traditional Japanese and Chinese medicine.

    Japanese Traditional Therapy, Honokiol, Blocks Key Protein in Inflammatory Brain Damage, Study Suggests
     
    sillysocks84, L'engle, Jarod and 2 others like this.
  2. Enid

    Enid Senior Member

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    Very interesting - thanks Wayne.
     
  3. angela

    angela

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    Hi Wayne, can you explain why you think this could explain why more women have autoimmune issues? I saw this on the protozoa thread and someone on my pots forum also made the arguement on why women are 4x as likely to be affected if protozoa has anything to do with chronic illness.
     
  4. Wayne

    Wayne Senior Member

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    Hi Angela,

    Boy, I really couldn't say. I read a theory once that women tend to get Fibromyalgia and develop other autoimmune issues because they take many prescriptions that contain fluoride (which men don't take). Some people are super anti-fluoride, and they believe it explains a lot of the ME/CFS, FM and other women predominant illnesses that are so common these days. --- All just theoretical I guess.
     
  5. Ruthie24

    Ruthie24 Senior Member

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    When I was watching those videos from Dr. Klimas' conference in January, the one by Dr. Fletcher and ..sorry can't remember the gentleman's name from Canada...but he did a brilliant job of showing how the male and female immune systems are so hugely different. He broke it down to a basic electrical engineering circuit diagram and said that all the info for the male immune system could be captured in that one diagram.

    However, the female immune system he said would take that one circuit diagram plus 3 more copies of it, in order to be able to represent all the info contained in the female immune system. He said this was logical because pregnancy is not just a hormonal event, but also a major immune suppression event as well.

    Makes you wonder if females are more prone to auto immune diseases in part because the system is that much more complicated so there are that many more points along the path for things to break down?
     
    sillysocks84 likes this.
  6. beaverfury

    beaverfury beaverfury

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    Hi Wayne

    Almost a year later ...I've seen your post.

    Honokiol sounds tailor made for me/cfs. Analgesic, antidepressant, antithrombotic (i don't know if that makes it anticoagulant), neurotropic. Should downgrade microglial activation through suppressing NF-kB and TNF.

    Anyone out there tried it ?
     
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  7. xena

    xena

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    i think i'm going to give this a try. i have read that honokiol is a ppar gamma agonist and can suppress TNF / cytokine production. i am struggling w/ mold detox reactions so ... shoemaker prescribes actos or high dose fish oil for this but i am reluctant to take such high doses of fish oil (like 9 capsules a day) due to fatty acid imbalance which i guess only develops over time
     
    Wayne likes this.
  8. Wayne

    Wayne Senior Member

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    Hi @xena

    I never did get around to trying this myself. Please let us know how it works for you. :)
     
  9. energyoverload

    energyoverload Senior Member

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    Also activates LKB1-AMPK axis in various cell types. In line with Julia Newton's findings of AMPK response failure (no phosphorylated AMPK (in skeletal muscle culture post stimulation, would be interesting if anyone has tried high dose Honokiol to see if this deficit is rectifiable provided there is not relative absence of LKB1 or impaired protein kinase integrity in ME patient muscle/neurons as is the case in some tumours.

    "HepG2 cells were treated with honokiol to examine whether 270 this compound activates LKB1, an upstream regulator of AMPK phos- 271 phorylation. The level of total LKB1 protein was not changed 272 with honokiol treatment, but phosphorylated LKB1 was dramatically increased 10–120 min after the addition of 100 μM honokiol 275 (Fig. 5A). In addition, honokiol increased the level of phosphorylated 276 LKB1 in a concentration-dependent manner"

    Paper here: http://www.ncbi.nlm.nih.gov.sci-hub.io/pubmed/25737164
     

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