The 12th Invest in ME Conference, Part 1
OverTheHills presents the first article in a series of three about the recent 12th Invest In ME international Conference (IIMEC12) in London.
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Planned supplements to review/tweak based on symptoms (+23andme results/LAB)

Discussion in 'Genetic Testing and SNPs' started by foxtrot81, Oct 17, 2017.

  1. foxtrot81

    foxtrot81

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    Dear all,

    I'm a 36yo male with the following symptoms and lab/genetic results... I've came up with a supplementation/lifestyle path to follow and would like to have some opinions if you think those are good starting points. I know it's a long way to go but need to start somewhere...

    Some questions are at the end of the post...

    I am seeing a good ENDO with me but things are going slow and we are on the early phase so I'd like to review this with you lovely people...

    SYMPTOMS
    - Loss of libido/desire, mild Viagra/Cialis effect, very low sperm volume
    - No morning wood (erections)
    - No spontaneous sexual thoughts
    - Low nitric oxide/NO (as per test strips) - affecting quality of erections...
    - Serious Mood swings, anxiety (calm exterior, inner tension)
    - No depression (usually "ok/happy" but not depressed at all...)
    - Constant stuffed nose and reduced smell (when it goes away seem to get my libido back)
    - Occasional tinnitus without explanation
    - No sweating/body odour
    - More neurotic/obsessive behaviour
    - Very good sleeper, never have problem with that
    - Heat intolerance, function well on cold places
    - Good Pain tolerance
    - Body skin feels cold to others
    - Rarely get sick or a cold
    - Very good digestion (no GI problems aware), good and periodic stools. No pain/acidity.
    - Lazy/sleepy after meals
    - No addictions
    - Sparse body hair
    - Short term memory problems (good long term)
    - Prefer solitary activities/sports
    - Lack of motivation
    - No alcohol-induced euphoria
    - No dreams/cannot recall them

    RELEVANT LABS
    LOWER RANGE:
    Chloride, FSH, IGF-1, Testosterone (14 nmol/L), Nitric Oxide (mornings - test strips)
    SWINGING (High/Low): Bicarbonate, Ferritin, HDL
    HIGH RANGE: ALT, Uric Acid, Fasting Blood Glucose, HA1C, Cholesterol, LDL, Homocysteine (12), CRP (3.5), Lp-PLA2 (260), Fibrinogen, Vitamin B6, Copper, Prolactin, Microalbumin/Creatinine ratio (6.21)
    Allergic to: Dust Mite (already with HEPA room filter + bed encasement + steam cleaning)

    23andME results:
    COMT V158M rs4680 AG +/-
    COMT H62H rs4633 CT +/-

    COMT P199P rs769224 GG -/-
    VDR Bsm rs1544410 CT +/-
    VDR Taq rs731236 AG +/-

    MAOA R297R rs6323 TT +
    MAOA rs2072743 T +
    MAOA T1011C rs1137070 C +
    MAOA T89113C rs2072743 C +
    MAOB rs1799836 C +
    MAOB A118723G rs1799836 C +

    ACAT102 rs3741049 GG -/-
    MTHFR C677T rs1801133 AG +/-
    MTHFR 03 P39P rs2066470 GG -/-
    MTHFR A1298C rs1801131 TT -/-
    MTR A2756G rs1805087 AA -/-
    MTRR A66G rs1801394 AA -/-

    MTRR H595Y rs10380 __ no call
    MTRR K350A rs162036 AG +/-
    MTRR R415T rs2287780 __ no call
    MTRR A664A rs1802059 GG -/-
    BHMT02 rs567754 CC -/-

    BHMT04 rs617219 __ no call
    BHMT08 rs651852 CT +/-
    AHCY01 rs819147 CT +/-

    AHCY02 rs819134 __ no call
    AHCY19 rs819171 CT +/-
    CBS C699T rs234706 AG +/-

    CBS A360A rs1801181 GG -/-
    CBS N212N rs2298758 __ no call
    SHMT1 C1420T rs1979277 __ no call


    Also HOMO and HETERO mutations at several other: CYP1A-GPX-GSTP-NAT (Detox), COMT-DAOA-GAD-MAOA-MAOB (Neurot.), SOD (Nitric Oxide), BH4, ADIPOQ-ESR-G6PC, NR3C, VDR (HPA Axis) and Cardio SNPs


    PLANNED DAILY SUPPLEMENTS
    Vitamin A: 3000IU
    Vitamin C (Ascorbic): 1000mg
    Vitamin D3: 2000IU
    Vitamin E (d-alpha and mixed): 75IU / 5mg
    Vitamin K2 (MK7): 100mcg
    Vitamin B1 (Thiamin Hydro): 65mg
    Vitamin B2 (Riboflavin 5-Phosph): 35mg
    Vitamin B3 (Niacin and Niacimide): 100mg
    Vitamin B5 (d-Calcium Panto): 100mg
    Vitamin B6 (P5P): 45mg
    Vitamin B7 (50% 5-MTHF and 50% Folinic Acid): 800mcg
    Vitamin B12 (50% as Methyl and 50% as Adeno): 650mcg
    Vitamin H (Biotin): 580mcg
    Iodine: 100mcg
    Magnesium: 1000mg
    Zinc (Bisglynate Chelate): 30mg
    Selenium: 75mcg
    Manganese: 4mg
    Chromium Chelate): 800mcg
    Molybdenum (Chelate): 400mcg
    Boron (Glycine): 5mg
    Vanadium: 750mg
    Myo-Inositol: 100mg
    Choline (Bitartrate): 90mg
    Lutein: 6mg
    Copper: 2mg
    Pycnogenol: 200mg
    L-Citrulline: 2400mg

    DIET CHANGES:
    Foods LOW in: Methionine, Thyramine, Tryptophan, Tyrisine, Taurine, Histaminic, MAO-I, Glutamate.


    QUESTIONS
    - Add CoQ10? (Methyl-donor)
    - Niacin is too much? (MAO-I or COMT-I?)
    - Is it good to start with a mix of Methyl and Adeno?
    - B12 Hydro: lowers NO?
    - Lutein: MAO-I?
    - Pycnogenol/Citrulline: Good dosage to restore NO/ED? (not libido, but might help)
    - CBS mutations to address first have been disputed in many websites: any thoughts here?
    - Would Citrulline overload the BH4/SOD/NO impaired cycle? (read about Arginine but don't know about Citrulline warnings)
    - Should I really add EPA/DHA? what ratio would you recommend here?
    - Should I add any aminoacid or extra mineral?


    Many thanks!
    Luis


     
  2. CFS_for_19_years

    CFS_for_19_years Hoarder of biscuits

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    You do realize this is a forum for people with ME/CFS?
     

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