Dear all,
I'm a 36yo male with the following symptoms and lab/genetic results... I've came up with a supplementation/lifestyle path to follow and would like to have some opinions if you think those are good starting points. I know it's a long way to go but need to start somewhere...
Some questions are at the end of the post...
I am seeing a good ENDO with me but things are going slow and we are on the early phase so I'd like to review this with you lovely people...
SYMPTOMS
- Loss of libido/desire, mild Viagra/Cialis effect, very low sperm volume
- No morning wood (erections)
- No spontaneous sexual thoughts
- Low nitric oxide/NO (as per test strips) - affecting quality of erections...
- Serious Mood swings, anxiety (calm exterior, inner tension)
- No depression (usually "ok/happy" but not depressed at all...)
- Constant stuffed nose and reduced smell (when it goes away seem to get my libido back)
- Occasional tinnitus without explanation
- No sweating/body odour
- More neurotic/obsessive behaviour
- Very good sleeper, never have problem with that
- Heat intolerance, function well on cold places
- Good Pain tolerance
- Body skin feels cold to others
- Rarely get sick or a cold
- Very good digestion (no GI problems aware), good and periodic stools. No pain/acidity.
- Lazy/sleepy after meals
- No addictions
- Sparse body hair
- Short term memory problems (good long term)
- Prefer solitary activities/sports
- Lack of motivation
- No alcohol-induced euphoria
- No dreams/cannot recall them
RELEVANT LABS
LOWER RANGE: Chloride, FSH, IGF-1, Testosterone (14 nmol/L), Nitric Oxide (mornings - test strips)
SWINGING (High/Low): Bicarbonate, Ferritin, HDL
HIGH RANGE: ALT, Uric Acid, Fasting Blood Glucose, HA1C, Cholesterol, LDL, Homocysteine (12), CRP (3.5), Lp-PLA2 (260), Fibrinogen, Vitamin B6, Copper, Prolactin, Microalbumin/Creatinine ratio (6.21)
Allergic to: Dust Mite (already with HEPA room filter + bed encasement + steam cleaning)
23andME results:
COMT V158M rs4680 AG +/-
COMT H62H rs4633 CT +/-
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 CT +/-
VDR Taq rs731236 AG +/-
MAOA R297R rs6323 TT +
MAOA rs2072743 T +
MAOA T1011C rs1137070 C +
MAOA T89113C rs2072743 C +
MAOB rs1799836 C +
MAOB A118723G rs1799836 C +
ACAT102 rs3741049 GG -/-
MTHFR C677T rs1801133 AG +/-
MTHFR 03 P39P rs2066470 GG -/-
MTHFR A1298C rs1801131 TT -/-
MTR A2756G rs1805087 AA -/-
MTRR A66G rs1801394 AA -/-
MTRR H595Y rs10380 __ no call
MTRR K350A rs162036 AG +/-
MTRR R415T rs2287780 __ no call
MTRR A664A rs1802059 GG -/-
BHMT02 rs567754 CC -/-
BHMT04 rs617219 __ no call
BHMT08 rs651852 CT +/-
AHCY01 rs819147 CT +/-
AHCY02 rs819134 __ no call
AHCY19 rs819171 CT +/-
CBS C699T rs234706 AG +/-
CBS A360A rs1801181 GG -/-
CBS N212N rs2298758 __ no call
SHMT1 C1420T rs1979277 __ no call
Also HOMO and HETERO mutations at several other: CYP1A-GPX-GSTP-NAT (Detox), COMT-DAOA-GAD-MAOA-MAOB (Neurot.), SOD (Nitric Oxide), BH4, ADIPOQ-ESR-G6PC, NR3C, VDR (HPA Axis) and Cardio SNPs
PLANNED DAILY SUPPLEMENTS
Vitamin A: 3000IU
Vitamin C (Ascorbic): 1000mg
Vitamin D3: 2000IU
Vitamin E (d-alpha and mixed): 75IU / 5mg
Vitamin K2 (MK7): 100mcg
Vitamin B1 (Thiamin Hydro): 65mg
Vitamin B2 (Riboflavin 5-Phosph): 35mg
Vitamin B3 (Niacin and Niacimide): 100mg
Vitamin B5 (d-Calcium Panto): 100mg
Vitamin B6 (P5P): 45mg
Vitamin B7 (50% 5-MTHF and 50% Folinic Acid): 800mcg
Vitamin B12 (50% as Methyl and 50% as Adeno): 650mcg
Vitamin H (Biotin): 580mcg
Iodine: 100mcg
Magnesium: 1000mg
Zinc (Bisglynate Chelate): 30mg
Selenium: 75mcg
Manganese: 4mg
Chromium Chelate): 800mcg
Molybdenum (Chelate): 400mcg
Boron (Glycine): 5mg
Vanadium: 750mg
Myo-Inositol: 100mg
Choline (Bitartrate): 90mg
Lutein: 6mg
Copper: 2mg
Pycnogenol: 200mg
L-Citrulline: 2400mg
DIET CHANGES:
Foods LOW in: Methionine, Thyramine, Tryptophan, Tyrisine, Taurine, Histaminic, MAO-I, Glutamate.
QUESTIONS
- Add CoQ10? (Methyl-donor)
- Niacin is too much? (MAO-I or COMT-I?)
- Is it good to start with a mix of Methyl and Adeno?
- B12 Hydro: lowers NO?
- Lutein: MAO-I?
- Pycnogenol/Citrulline: Good dosage to restore NO/ED? (not libido, but might help)
- CBS mutations to address first have been disputed in many websites: any thoughts here?
- Would Citrulline overload the BH4/SOD/NO impaired cycle? (read about Arginine but don't know about Citrulline warnings)
- Should I really add EPA/DHA? what ratio would you recommend here?
- Should I add any aminoacid or extra mineral?
Many thanks!
Luis
I'm a 36yo male with the following symptoms and lab/genetic results... I've came up with a supplementation/lifestyle path to follow and would like to have some opinions if you think those are good starting points. I know it's a long way to go but need to start somewhere...
Some questions are at the end of the post...
I am seeing a good ENDO with me but things are going slow and we are on the early phase so I'd like to review this with you lovely people...
SYMPTOMS
- Loss of libido/desire, mild Viagra/Cialis effect, very low sperm volume
- No morning wood (erections)
- No spontaneous sexual thoughts
- Low nitric oxide/NO (as per test strips) - affecting quality of erections...
- Serious Mood swings, anxiety (calm exterior, inner tension)
- No depression (usually "ok/happy" but not depressed at all...)
- Constant stuffed nose and reduced smell (when it goes away seem to get my libido back)
- Occasional tinnitus without explanation
- No sweating/body odour
- More neurotic/obsessive behaviour
- Very good sleeper, never have problem with that
- Heat intolerance, function well on cold places
- Good Pain tolerance
- Body skin feels cold to others
- Rarely get sick or a cold
- Very good digestion (no GI problems aware), good and periodic stools. No pain/acidity.
- Lazy/sleepy after meals
- No addictions
- Sparse body hair
- Short term memory problems (good long term)
- Prefer solitary activities/sports
- Lack of motivation
- No alcohol-induced euphoria
- No dreams/cannot recall them
RELEVANT LABS
LOWER RANGE: Chloride, FSH, IGF-1, Testosterone (14 nmol/L), Nitric Oxide (mornings - test strips)
SWINGING (High/Low): Bicarbonate, Ferritin, HDL
HIGH RANGE: ALT, Uric Acid, Fasting Blood Glucose, HA1C, Cholesterol, LDL, Homocysteine (12), CRP (3.5), Lp-PLA2 (260), Fibrinogen, Vitamin B6, Copper, Prolactin, Microalbumin/Creatinine ratio (6.21)
Allergic to: Dust Mite (already with HEPA room filter + bed encasement + steam cleaning)
23andME results:
COMT V158M rs4680 AG +/-
COMT H62H rs4633 CT +/-
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 CT +/-
VDR Taq rs731236 AG +/-
MAOA R297R rs6323 TT +
MAOA rs2072743 T +
MAOA T1011C rs1137070 C +
MAOA T89113C rs2072743 C +
MAOB rs1799836 C +
MAOB A118723G rs1799836 C +
ACAT102 rs3741049 GG -/-
MTHFR C677T rs1801133 AG +/-
MTHFR 03 P39P rs2066470 GG -/-
MTHFR A1298C rs1801131 TT -/-
MTR A2756G rs1805087 AA -/-
MTRR A66G rs1801394 AA -/-
MTRR H595Y rs10380 __ no call
MTRR K350A rs162036 AG +/-
MTRR R415T rs2287780 __ no call
MTRR A664A rs1802059 GG -/-
BHMT02 rs567754 CC -/-
BHMT04 rs617219 __ no call
BHMT08 rs651852 CT +/-
AHCY01 rs819147 CT +/-
AHCY02 rs819134 __ no call
AHCY19 rs819171 CT +/-
CBS C699T rs234706 AG +/-
CBS A360A rs1801181 GG -/-
CBS N212N rs2298758 __ no call
SHMT1 C1420T rs1979277 __ no call
Also HOMO and HETERO mutations at several other: CYP1A-GPX-GSTP-NAT (Detox), COMT-DAOA-GAD-MAOA-MAOB (Neurot.), SOD (Nitric Oxide), BH4, ADIPOQ-ESR-G6PC, NR3C, VDR (HPA Axis) and Cardio SNPs
PLANNED DAILY SUPPLEMENTS
Vitamin A: 3000IU
Vitamin C (Ascorbic): 1000mg
Vitamin D3: 2000IU
Vitamin E (d-alpha and mixed): 75IU / 5mg
Vitamin K2 (MK7): 100mcg
Vitamin B1 (Thiamin Hydro): 65mg
Vitamin B2 (Riboflavin 5-Phosph): 35mg
Vitamin B3 (Niacin and Niacimide): 100mg
Vitamin B5 (d-Calcium Panto): 100mg
Vitamin B6 (P5P): 45mg
Vitamin B7 (50% 5-MTHF and 50% Folinic Acid): 800mcg
Vitamin B12 (50% as Methyl and 50% as Adeno): 650mcg
Vitamin H (Biotin): 580mcg
Iodine: 100mcg
Magnesium: 1000mg
Zinc (Bisglynate Chelate): 30mg
Selenium: 75mcg
Manganese: 4mg
Chromium Chelate): 800mcg
Molybdenum (Chelate): 400mcg
Boron (Glycine): 5mg
Vanadium: 750mg
Myo-Inositol: 100mg
Choline (Bitartrate): 90mg
Lutein: 6mg
Copper: 2mg
Pycnogenol: 200mg
L-Citrulline: 2400mg
DIET CHANGES:
Foods LOW in: Methionine, Thyramine, Tryptophan, Tyrisine, Taurine, Histaminic, MAO-I, Glutamate.
QUESTIONS
- Add CoQ10? (Methyl-donor)
- Niacin is too much? (MAO-I or COMT-I?)
- Is it good to start with a mix of Methyl and Adeno?
- B12 Hydro: lowers NO?
- Lutein: MAO-I?
- Pycnogenol/Citrulline: Good dosage to restore NO/ED? (not libido, but might help)
- CBS mutations to address first have been disputed in many websites: any thoughts here?
- Would Citrulline overload the BH4/SOD/NO impaired cycle? (read about Arginine but don't know about Citrulline warnings)
- Should I really add EPA/DHA? what ratio would you recommend here?
- Should I add any aminoacid or extra mineral?
Many thanks!
Luis
