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Pilot study: "Identification of anti-citrullinated protein antibodies in ‪CFS‬" plus call for funds

Discussion in 'Latest ME/CFS Research' started by Dolphin, Dec 11, 2015.

  1. Dolphin

    Dolphin Senior Member

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    Results of pilot study: "Identification of anti-citrullinated protein antibodies in ‪CFS‬"

    http://immunedysfunction.org/future15.html

    The Vermont ‪#CFIDS‬ Association aka ImmuneDysfunction.org wants to raise $27000 to do a larger study (see link)

    I think it would probably be better if people don't try to convert the image file into text for posting elsewhere as:
    (i) perhaps they will want to publish it;
    (ii) it could get separated from the call for funds for a larger study.
     
    nandixon, *GG*, waiting and 3 others like this.
  2. Bob

    Bob

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    Dolphin likes this.
  3. BurnA

    BurnA Senior Member

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  4. A.B.

    A.B. Senior Member

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    So... anti-citrullinated protein antibodies are frequently found in other diseases, reliable tests exist for measuring these antibodies for the purpose of diagnosing rheumatoid arthritis... and nobody has thought about ruling out this possibility in ME/CFS before this study?
     
    Last edited: Dec 11, 2015
    leela likes this.
  5. Snow Leopard

    Snow Leopard Hibernating

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    Positives: 7/25 patients, 2/25 controls in the pilot study...

    https://en.wikipedia.org/wiki/Anti–citrullinated_protein_antibody

    Target citrullinated antigens in RA, including fibrinogen, deiminated Epstein-Barr Virus Nuclear Antigen 1 and vimentin...

    See also:
    https://en.wikipedia.org/wiki/Citrullination

    Additional edit:
    What drives deimination?

    There seems to be some discussion of deimination of small cyokines (chemokines) such as CXCL8, CXCL10, CXCL11 and others.

    What about deimination of GPCRs? Does this serve any functional purpose or would it only happen by accident?
     
    Last edited: Dec 11, 2015
    Bob, RL_sparky and SOC like this.
  6. alex3619

    alex3619 Senior Member

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    One of the things that is suggestive and intriguing about this study, but far from proven to be important, is that a third of patients is about the proportion of Rituximab patients who respond and we have not yet found any antibody to investigate. Depending on where the research goes this could prove interesting.
     
    leela, L'engle, Webdog and 2 others like this.
  7. BurnA

    BurnA Senior Member

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    I thought it was closer to two thirds response for rtx.
     
    Webdog likes this.
  8. adreno

    adreno PR activist

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    Could this be related to the fact that both arginine and citrulline makes my symptoms markedly worse?
     
    leela and John Mac like this.
  9. Gijs

    Gijs Senior Member

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    There are several positive antibodies found in CFS patients. What is causing this. Could it be due to impaired function of B cells? In that case, I think that EBV -living in B cells- may be a major player.
     
  10. John Mac

    John Mac Senior Member

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    Same for me. Tried starting these supplements 3 times and each time felt lousy.
     
  11. Bob

    Bob

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    I seem to remember the Norway rituximab studies having a two-thirds response rate overall and roughly a 50% response rate when compared to the control group. But my memory is bad.
     
    BurnA likes this.
  12. Jenny

    Jenny Senior Member

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    funkyqueen likes this.
  13. alex3619

    alex3619 Senior Member

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    They have identified possible autoantibody mechanisms in roughly half the responders, which leaves half completely unaccounted for. The finding in the paper in this thread potentially, and this is not proven at all, may account for that other half.
     
    Webdog, SOC and Bob like this.
  14. alex3619

    alex3619 Senior Member

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    Patent applications typically cover a range of options. They seek to secure rights before the research is finalized. Citrulline, by itself, and citrullilne modified proteins, are not the same thing. One does have to wonder though what conditions would permit citrulline to worsen the protein damage.
     
    Jenny likes this.
  15. Bob

    Bob

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    Ah, I see what you mean now. Thanks for clarifying, Alex.
     
    funkyqueen likes this.
  16. Jonathan Edwards

    Jonathan Edwards Senior Member

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    It would be easy to replicate in all ME/CFS service units and it would be worth checking out. I would like to see the actual readings for each patient before commenting on the data. Two positives in 25 controls is not quite as expected. One would have thought they would make sure the controls did not have RA in advance! The description of the study seems a bit naive but there is no harm in that if the results are repeatable. I would be a bit surprised if a third of patients with ME had ACPA since ACPA would be a pretty standard screen for someone with fatigue and limb pain these days.
     
  17. SOC

    SOC

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    Interesting point. This should have been picked up if ME patients are routinely tested. Let's do a casual poll... Who has had an ACPA screen as part of their ME assessment? Is the test more commonly given in some countries than others?

    I have not had this test and I am in the US.
     
  18. adreno

    adreno PR activist

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    I never had this, or any other antibody tests conducted.
     
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  19. Sidereal

    Sidereal Senior Member

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    I've had this tested and it was negative.
     
    merylg, L'engle, Snow Leopard and 2 others like this.
  20. A.B.

    A.B. Senior Member

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    I don't think I've had this test. I've had a couple for rheumatoid arthritis (waaler rose and rheumatoid factor) but these don't detect anti-citrullinated protein antibodies right?
     
    L'engle and Snow Leopard like this.

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