1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
Can You Come for a Visit? My ME/CFS Says No
My daughter and son-in-law just had a baby last week. We are thrilled. But we won't be able to see the baby or hold her any time soon. We won't be able to take over little gifts or help out with housework or babysitting.
Discuss the article on the Forums.

Phosphatidylserine brand and dosage help needed

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by topaz, Jan 25, 2012.

  1. topaz

    topaz Senior Member

    Messages:
    148
    Likes:
    3
    Hi

    Ive posted about my high cortisol before and have decided to try Phosphatidylserine. Ive searched the posts and it appears to have helped some users although it is not widely commented on.

    Rich - I know that you recommend a brand but this is not sold on iherb and I would prefer to purchase from one site as I am overseas.

    Is a phosphatidylserine complex recommended over straight phosphatidylserine?

    Is soy lecithin source preferrable to bovine source for this (btw, all the brands that Ive looked at on iherb are lecithin based)?

    What brands and dose are recommended?

    Interestingly, phosphatidylserine's primary benefits are touted as memory and cognitive improvements on iherb (and presumeably by the manufacturers themselves as they supply the info) although I will be using it to lower cortisol (which is not mentioned in the descriptions of the brands that I have looked at on iherb).

    Thanks in advance for help
  2. penny

    penny Senior Member

    Messages:
    286
    Likes:
    134
    Southern California
    Just my personal experience with serine:

    I take 600mg of serine a day, which is a lot I believe. I had blood tests (NutraEval from Genova) which showed I was deficient in a number of amino acids and recommended dosages. They actually recommended 733mg (a totally awkward number), and it's an expensive supplement at these dosages, so I erred on the lower side, thus the 600mg.

    I buy these: http://www.iherb.com/Jarrow-Formulas-PS-100-100-mg-60-Softgels/273?at=0
    Specifically the softgels, I think they work better (though I don't really know) and they are nice and easy to swallow.
    (Though I usually get my supplements from Amazon)

    I was taking these during the day because I thought it helped with cognitive functioning, and that seemed to be when I'd want better cognitive functioning! But I also have high cortisol (I've tested high in the morning and have the 'symptoms' of high levels in the evening, never tested for evening levels), so after reading your other thread I've switched to an evening dosage. We'll see if that helps with the unpleasant wired feeling...

    ps. I don't know if it's possible to buy the bovine based serine anymore. I think I looked into it a while back because some of the studies that showed benefits of serine used that rather than the soy. Anyway, I'm pretty sure I couldn't find it for sale, though it might be different outside of the US.
  3. hixxy

    hixxy Woof woof

    Messages:
    724
    Likes:
    106
    Russell Island, Australia
    I'm just about to try phosphatidylserine for the same reason and I chose Doctor's Best, Best Phosphatidyl Serine, 100 mg, 120 Veggie Caps from iherb because it contains very little other phospholipids. I find phosphatidylcholine stimulating.

    I'll post back with my experience!

    hixxy
  4. heapsreal

    heapsreal iherb 10% discount code OPA989,

    Messages:
    7,150
    Likes:
    4,409
    australia (brisbane)
    i use drs best brand from iherb as they seem the best priced. I initially used it at night to help sleep through lowering night time cortisol and it did help some, and then i changed to morning dose as i have read articles saying it can help improve speed up brain function, dont think this helped much. But last night i started taking it again at night and my sleep was definately improved as apart of my sleep combo, so will continue using it at night now, i just take 1 x 100mg cap, seems to do the job. Phos serine 100mg with 3000mg of tryptophan taken at night on an empty stomache i have found can make me feel abit drugged out and sleep improves.

    cheers!!!
  5. topaz

    topaz Senior Member

    Messages:
    148
    Likes:
    3
    Thanks heapsreal and hixxy82

    Your experience with the different timings of dosages is helpful healspreal.

    I am still torn between 'pure' phosphatidylserine and phosphatidylserine complex. Ordinarily I prefer to purchase single ingredient supplements however Amy Yasko/Rich recommend the phosphatidylserine complex from holisticheal (http://www.holisticheal.com/phosphatidyl-serine-complex-pspepc.html) and not the phosphatidylserine-only product.

    The one recommended by Rich contains the following:

    Phosphorus 10 mg
    Potassium 3 mg
    Phosphatidyl serine complex: 500 mg
    ~Phosphatidylserine 100 mg
    ~Phosphatidylcholine 55 mg
    ~Phosphatidylinositol 10 mg
    ~Phosphatidylethanolamine 20 mg
    ~Linolenic acid 10 mg
    ~Linoleic acid 85 mg
    ~Oleic Acid 15 mg
    ~Palmitic Acid 27 mg
    ~Stearic acid 6 mg
    ~Capric acid 51 mg
    ~Caprylic acid 120 mg

    I also saw a youtube (sorry, unable to recall source) recommending 100ml Phosphatidylserine with 1tspn of d-ribose as a great stress reliever "cocktail" following a stressful day, especially if have events to attend in the evening.

    Anyway, I still remain on the fence and uncertain whether to get the complex or only the single ingredient Phosphatidylserine \.
  6. penny

    penny Senior Member

    Messages:
    286
    Likes:
    134
    Southern California
    It may be coincidence but the week I took my serine in the evening, I had more difficulty with cognitive functioning. So I've switched back to daytime doses and my cognitive functioning is back to my recent normal.

    Also, because of this thread, I spent some time searching google for articles about serine and cortisol, I found a couple of interesting articles that discussed how serine dampens the cortisol reaction to exercise and to stress. I didn't see, though I may have missed it, articles mentioning lowering base line cortisol. But reducing stress/excercise cortisol reaction seems really useful for us, since very mild activity / stress has an exaggerated impact. Interestingly the effective dose is different between different studies, one showed no significant effect below 800mg a day, and another showed an effect at 400mg but NOT at 600mg or 800mg. Weird.

    A few of the articles:
    Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men
    http://www.springerlink.com/index/RV8R3551T2235342.pdf

    Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans
    http://informahealthcare.com/doi/abs/10.1080/10253890410001728379

    The effects of phosphatidylserine on endocrine response to moderate intensity exercise
    http://www.springerlink.com/content/m11v647w35516146/

    (hopefully these links work...)
  7. topaz

    topaz Senior Member

    Messages:
    148
    Likes:
    3
    Thanks penny

    I will try to find the links I came across regarding using PS to lower cortisol but as my night time cortisol is high ie rising throughout the day rather than starting high and falling, it is likely to be a response to stress and hence PS may help.

    I was listening to Rich vank's lecture and he specifically mentioned reduced phosphatidylcholine found in PWC's so on that basis, I have decided to go with a PS Complex (to ensure that phosphatidylcholine is included together with PS).

    Thanks
  8. penny

    penny Senior Member

    Messages:
    286
    Likes:
    134
    Southern California
    Good luck! I hope it helps : )

See more popular forum discussions.

Share This Page