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Phenibut from Bulk Powders And RU486 mifepristone

Discussion in 'General Treatment' started by xptriado, Jun 1, 2015.

  1. xptriado

    xptriado Senior Member

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    So two questions. Has anyone tried Phenibut from Bulk Powders? Is it any good? Apparently people talk well about liftmode phenibut...
    Is it really as addictive as people make it sound? Over at FTPO groups in facebook, i see lots of people taking it daily ?!

    And another question: has anyone tried an accute dosage of mifepristone to reset the HPA axis for good? Is this dangerous?

    Resets hpa with a few pills and effects stick around afterwards. I think it is resetting receptors/signaling in hypothalamus and is healing, not treating.

    https://www.utexas.edu/pharmacy/divisions/pharmaco/rounds/snyder02-10-12.pdf


    http://www.hindawi.com/journals/drt/2012/393251/



    http://www.longecity.org/forum/topic/64289-mifepristone-for-depression-hpa-axis-dysfunction/

    https://www.facebook.com/PtsdHope/posts/602887143112056
     
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  2. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Phenibut is sedating and tolerance occurs quickly . I think I have read about using it once every 5 days?? Helps avoid tolerance and addiction .

    Ru486 i recall can increase nk function. This is one mechanism of it causing spontaneous abortions . Haven't heard very much at all about it being used in cfs. Maybe cost is a factor.
     
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  3. xptriado

    xptriado Senior Member

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    Its a one time thing. Would be costly but just once.

    I only heard of it for ptsd. There is a phase II trial going on.
     
  4. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    I could be wrong but i remember many years ago bodybuilders looking into it as it lowers cortisol and can improve their anabolic ratio.

    Not sure if lowering cortisol in cfs would be a good thing as many are already low. I think it effects several mechanisms ? ?
     
  5. minkeygirl

    minkeygirl But I Look So Good.

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    My phenibut bottle says don't take it more than 3 days in a row.
     
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  6. xptriado

    xptriado Senior Member

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    Yes and i think its still.used.

    Apparently it affects also mineralcorticoids.
    I think it is working.as well for low cortisol profiles?
    Im curious about it, i will research some more. Up until now i didnt find many brave people who tried it and wrote back.

    I guess phenibut is just like a benzo.

    Anyway, do you know if the one from bulkpowders.co.uk is any good?
     
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  7. renerdrat

    renerdrat Every teardrop is a waterfall

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    Temecula
    interesting seeing this here, and that link... I post on that site and thread frequently hah. I bought 10g of mifepristone, i tried it, it didn't help me personally, but I do think it has potential for sure. I used one of the verrified sellers on this site: http://manufacturer.ec21.com/mifepristone.html
     
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  8. xptriado

    xptriado Senior Member

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    you bought 10g of mifepristone? how much did that cost? did you test it? was it real mifepristone?
     
  9. Hip

    Hip Senior Member

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    May I ask, did you have to say that you were a company rather than an individual in order to buy mifepristone powder via this ec21.com website that lists wholesale manufacturers?

    I have in the past bought from such wholesale manufacturers in China, but I had to say I was a trading company, because the wholesaler did not do business with individuals.
     
    Last edited: Jun 19, 2015
  10. renerdrat

    renerdrat Every teardrop is a waterfall

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    um I honestly don't remember, I think I put some company I "represented" but didnt' even think about presenting myself like I was a company and not an individual. I could give you the person that I bought from if interetesed.
     
  11. Hip

    Hip Senior Member

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    Thanks renerdrat.

    I have actually now contacted four different people from ec21.com who are selling mifepristone powder in small 10 gram amounts, and most of them replied within 24 hours, offering 10 grams for prices ranging from $45 to $80. Though these suppliers were asking quite a lot for courier shipping, around $60. I am going to ask them if they can send by regular mail, which should be much cheaper.
     
  12. panckage

    panckage Senior Member

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    @xptriado the liftmode phenibut should be fine. I would recommend looking at the recommended (haha) vendors on https://www.reddit.com/r/Nootropics/ for this. Apparently all the powders come from China. The difference is that the recommended vendors test the powders they purchase to make sure they are what they claim they are. They will email customers and publicly announce any powder they have that has issues with it

    @Hip from what I have read just tell them that you are a company and need a sample. Most will be happy to sell a smaller amount
     
    Last edited: Sep 3, 2015
  13. Jesse2233

    Jesse2233 Senior Member

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    @Hip did you ever end up trying mifepristone?
     
  14. Hip

    Hip Senior Member

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    No I didn't, but I am pleased your reminded me of this drug, as I would still like to try it.

    The trouble is trying find an inexpensive source: even the cheap overseas pharmacies in India etc sell mifepristone at around $100 for just one 200 mg pill.

    If you look at this study in which mifepristone (RU 486) was used to treat major depression, they used a dose of 200 mg daily for up to eight weeks. That would make a course of mifepristone experiment incredibly expensive, in the order of $5000.

    Another study using mifepristone for psychotic major depression used an even higher dose of 600 to 1,200 mg, but just for 7 days.

    And a similar study for psychotic major depression used 600 mg of mifepristone daily for just four days, which resulted in substantial improvement in both depression and psychosis; this study commented that by abruptly blocking the glucocorticoid type II receptors, mifepristone
    So it looks like a short 4 day course of mifepristone at 600 mg daily can achieve this HPA axis reset, which may have long term benefits.

    The above study says that mifepristone is a glucocorticoid type II receptor antagonist, but has very little effect on type I receptors.

    Rash was a common side effect with mifepristone use (see the section entitled "Side effects of chronic mifepristone administration" in this paper). But if you are only taking mifepristone for 4 days, that hopefully may be too short a time for the rash to manifest.



    Looking on www.ec21.com, there are still many people selling mifepristone powder, so that seems like a viable source of inexpensive mifepristone.
     
    Last edited: Nov 17, 2017 at 6:28 AM

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