Nielk
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From Wikipedia
I wonder if anyone is familiar with this.
The reason why I became interested is because I started to look into the fact that different people metabolize medications at different rates - probably due to genetics. this might partly explain why different people react differently to specific medications and/or need different dosages.
I believe that I might be a "fast oxidizer" and I base this conclusion on the fact that a few months ago, I had to detox from Klonopin - 3mg a day. I had a blood test taken the morning after I stopped taking it and it showed no
level of Klonopin in my system. Whereas someone else in the same situation still had it show up 3 weeks later.
I wonder how much of an effect a person's rate of medication metabolism has on the efficiency of the drug.
ADME
Pharmacokinetics is divided into several areas including the extent and rate of absorption, distribution, metabolism and excretion. This is commonly referred to as the ADME scheme:
Elimination is the result of metabolism and excretion.
- Absorption - the process of a substance entering the blood circulation.
- Distribution - the dispersion or dissemination of substances throughout the fluids and tissues of the body.
- Metabolism (or Biotransformation) - the irreversible transformation of parent compounds into daughter metabolites.
- Excretion - the removal of the substances from the body. In rare cases, some drugs irreversibly accumulate in body tissue.
Pharmacokinetics describes how the body affects a specific drug after administration. Pharmacokinetic properties of drugs may be affected by elements such as the site of administration and the dose of administered drug. These may affect the absorption rate.[2]
A fifth process, Liberation has been highlighted as playing an important role in pharmacokinetics:[3][4]
Hence LADME may sometimes be used in place of ADME in reference to the core aspects of pharmacokinetics.
- Liberation - the process of release of drug from the formulation.
I wonder if anyone is familiar with this.
The reason why I became interested is because I started to look into the fact that different people metabolize medications at different rates - probably due to genetics. this might partly explain why different people react differently to specific medications and/or need different dosages.
I believe that I might be a "fast oxidizer" and I base this conclusion on the fact that a few months ago, I had to detox from Klonopin - 3mg a day. I had a blood test taken the morning after I stopped taking it and it showed no
level of Klonopin in my system. Whereas someone else in the same situation still had it show up 3 weeks later.
I wonder how much of an effect a person's rate of medication metabolism has on the efficiency of the drug.