Jesse2233
Senior Member
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Hey everyone,
I've stumbled across a new drug called Pexidartinib (PLX-3397) that repopulates microglia. It's currently being trialed for cancer and tumors.
I've not seen this drug discussed anywhere in regards to ME/CFS
From a study using adult mice:
So far there have been some liver toxicity side effects in human trials. But if one only needed to take the drug once to restore healthy microglia then it might be worthwhile.
Of course the big caveats are:
I've stumbled across a new drug called Pexidartinib (PLX-3397) that repopulates microglia. It's currently being trialed for cancer and tumors.
I've not seen this drug discussed anywhere in regards to ME/CFS
From a study using adult mice:
Surprisingly, extensive treatment results in elimination of ~99% of all microglia brain-wide, showing that microglia in the adult brain are physiologically dependent upon CSF1R signaling. Mice depleted of microglia show no behavioral or cognitive abnormalities, revealing that microglia are not necessary for these tasks. Finally, we discovered that the microglia-depleted brain completely repopulates with new microglia within one week of inhibitor cessation
So far there have been some liver toxicity side effects in human trials. But if one only needed to take the drug once to restore healthy microglia then it might be worthwhile.
Of course the big caveats are:
- Microglia may not be central to ME pathology
- The new microglia may simply get reprimed when they grow back by some other causal factor
- Wiping out part of the brain's immune system may not be a good idea if there's a virulent chronic pathogen