I've come across a few posts on the Perrin Technique lately and in the ME Association's survey, 115 PWC had tried the technique and 51% considered it to have improved their symptoms (14% "greatly improved" and 37% "improved"). It's a technique developed by an osteopath that involves light massage and exercises to improve lymph drainage. The technique's originator (a PhD, not a medical doctor) has treated a lot of ME/CFS patients and on his Perrin Clinic website says: "We at the Perrin Clinic believe that Chronic Fatigue Syndrome/Myalgic Encephalitis and Post Viral Fatigue Syndrome is a physical disorder that leads to a build up of toxins within the brain and the spine. The Perrin Technique™ has been developed to diagnose CFS/ME by identifying definite physical signs and to treat the disorder by improving drainage of these poisons from the central nervous system. [...] "Raymond Perrin's research at the University of Salford in conjunction with the University of Manchester has provided strong evidence that an important component of CFS/ME involves a disturbance of lymphatic drainage of the brain and muscles. The novel osteopathic treatment developed by Raymond Perrin has been statistically validated in both clinical trials, emphasising the need to focus future research on the biomechanical aspects of this disorder. Raymond has expanded our knowledge of CFS/ME, which led to a doctorate awarded by the University of Salford." I must admit that when a practitioner starts talking about "toxins" and "poisons" it sounds vague and alarmist to me; I'd rather they specify what they mean, although in a video on the site it appears that the "toxins" he's talking about are specific immune products (macrophages and stuff, I think - I'm no biologist). And he is talking about a different method of diagnosing ME/CFS than, say, the Canadian Consensus or other criteria, based on physical signs and symptoms including a flattened thoracic spine as you can see in his YouTube stuff (at 1:50 to 2:30 mins in this section). So I'm not sure whether he's really treating ME/CFS patients as we'd recognise them though it's possible that such patients are approaching him for treatment and he's just "confirming the diagnosis". I've skim-read some of his stuff at this point and I hope I'm not misrepresenting him but for me he rings alarm bells in terms of the manner of his claims while on the other hand, I gather it makes sense to get your lymph system moving because it carries immune system "messengers" around the body and disposes of waste, but relies on the movement of your body to function (it doesn't have a pump like the blood system has the heart). So if you're not moving much, neither is your lymph. So, a few questions. Pick any one(s) you like! 1. Anybody with a proper background in biomedical stuff have an opinion on whether the basic approach makes any sense? 2. That flattened spine thing: is that something that can develop in people with an illness, say, through long periods of being confined to bed? I hadn't heard that the spine could change shape in adults except through osteoporosis. If so, can it be changed back to normal? I'd be amazed if that were so but maybe I will be. 3. The above blurb mentions that he's done a couple of clinical trials (I think they might have formed part of his PhD). Does anyone know where there's a summary? I'm interested in their design quality, his results, and how he is defining ME/CFS. 4. Some of the exercises in the video on his site (shoulder rolls, marching on the spot, twisting from side to side) are identical to some I've just been given by a physio to sort my back out. Is it possible that his techniques help people with pain symptoms but for different reasons than he thinks? Please feel free to add other questions of your own or comments on the Perrin technique or lymph massage/drainage generally!