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Perque Vessel Guard

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Sallysblooms, Apr 4, 2011.

  1. Sallysblooms

    Sallysblooms P.O.T.S. now SO MUCH BETTER!

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    Southern USA
    What is the Mannitol used for in Perque Vessel Guard? it is transported to the brain and organs with it, correct? Does anyone use Perque?
     
  2. Freddd

    Freddd Senior Member

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    Salt Lake City

    http://en.wikipedia.org/wiki/Mannitol
    Mannitol is a sugar alcohol; that is, it is derived from a sugar by reduction, with a molecular weight of 182.17 g/mol,[3] and a density of 1.52 g/mL.[4] Other sugar alcohols include xylitol and sorbitol. Mannitol and sorbitol are isomers, the only difference being the orientation of the hydroxyl group on carbon 2.[5] Aqueous solutions of mannitol are mildly acidic and sometimes such solutions are treated to lower the pH
    ...
    Mannitol is used clinically in osmotherapy to reduce acutely raised intracranial pressure until more definitive treatment can be applied, e.g., after head trauma. It is also used to treat patients with oliguric renal failure. It is administered intravenously, and is filtered by the glomeruli of the kidney, but is incapable of being resorbed from the renal tubule, resulting in decreased water and Na+ reabsorption via its osmotic effect. Consequently, mannitol increases water and Na+ excretion, thereby decreasing extracellular fluid volume.
    Mannitol can also be used as a facilitating agent for the transportation of pharmaceuticals directly into the brain. The arteries of the blood-brain barrier are much more selective than normal arteries. Normally, molecules can diffuse into tissues through gaps between the endothelial cells of the blood vessels. However, what enters the brain must be much more rigorously controlled. The endothelial cells of the blood-brain barrier are connected by tight junctions, and simple diffusion through them is impossible. Rather, active transport is necessary, requiring energy, and only transporting molecules that the arterial endothelial cells have receptor signals for. Mannitol is capable of opening this barrier by temporarily shrinking the endothelial cells, simultaneously stretching the tight junctions between them.
     
  3. Freddd

    Freddd Senior Member

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    Hi Sallysblooms,

    Consider what is in Perque Vessel Guard; B6, Folinate (folinic acid) and hydroxcbl. It is for homocysteine reduction. It also has xylitol as well as mannitol and sugar (dried "cane juice").

    The amount of mannitol, 198mg, is well below the amount used, about 500mg/kilo-body-weight IV for aiding blood brain barrier penetration. It is one of 3 sweetners used in it along with cherry flavor.

    In other words it is all inactive forms of the vitamins. If folinic acid causes paradoxical folate deficiency for a person then it is a major problem with 2500mcg of folinate.
     

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