Severe ME Day of Understanding and Remembrance: Aug. 8, 2017
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pentoxifylline

Discussion in 'General ME/CFS Discussion' started by Bdeep86, Jun 4, 2015.

  1. Bdeep86

    Bdeep86 Senior Member

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    I have been reading about this medication for its microglial and anti inflammatory properties. I did a search on here and it didn't yield much as far as anecdotal reports. Has anyone trailed this?
     
  2. Hip

    Hip Senior Member

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    You might want to do a search on the related drug propentofylline, as you will find more info on this.
     
  3. CFS_for_19_years

    CFS_for_19_years Hoarder of biscuits

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    There are a few posts here under the trade name Trental.
     
  4. adreno

    adreno PR activist

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    It gave me a massive headache. And hives.
     
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  5. Ema

    Ema Senior Member

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    I actually just got a script for this to reduce inflammation.

    I hope it doesn't give me hives!!
     
    nandixon likes this.
  6. Eeyore

    Eeyore Senior Member

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    I tried it for a time. It initially gave me a headache, but that went away with time. I lost a lot of weight on it - had no appetite at all. Overall, I'm not sure that it helped, although it did seem to help a bit with inflammation (redness in face lessened, less dry eye, etc.)

    It does increase bleeding tendency, and many ME patients have elevated tPA to start, and sometimes abnormal clotting and/or fibrinolysis, and antiphospholipid syndrome is not uncommon (although I don't have it). If you have any tendency to bleed you need to be careful - and INR would be sensible to check in advance as well as some basic measures of fibrinolysis - including d-dimer/FDP and t-PA.

    In general, I think it's a pretty safe med and a decent inflammatory. I'm not sure it really helps a lot in ME though - I've yet to hear of it really having a great effect in anyone.

    I wonder if the headache is a general effect or something particularly common in ME.
     

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