Many of you have provided both advice and support in my healing journey and I am enormously grateful. You’ve helped me to feel not quite so alone, have taken the edge off a very scary process and given me tools to move forward. Most of all you’ve made me feel less stuck. Because of my family history—my mother and an older sister dead from breast cancer far too young, my baby sister living with it, I have a particular interest in approaches to this challenging disease. Though genetic counseling has shown I do not have the BRCA2 gene, both my sisters have/had it (not my mother, most likely, as she developed it post-menopausally, whereas my father’s sister, like my own, developed it pre-menopausally, leading counselors at Dana Farber to suggest it was most likely passed down by my father). In any case, it’s this clear-cut effect of genetics that has led me to PR’s methylation protocols and one of the threads here where @ppodhajski happened to mention the University of North Carolina’s work on Nutrigenomics. For this bit of serindip, a bow to him. My own curiosity led me along the path of the head of the Department of Nutrition at that school, Dr. Steven Zeisel, whose credentials are stellar: Harvard Medical, MIT PhD in Nutrition. It’s Dr. Zeisel’s work I want to bring to the awareness of members who are interested. In my research, which has been in no way exhaustive, I came upon enough pertinent journal articles co-authored by him to make me aware of the importance of choline for those struggling with breast cancer. I want to share the work I’ve compiled which includes information about Dr. Zeisel (all highlighted print is my own), and four articles he has helped to pen: ‘Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans,’ ‘Choline metabolism and risk of breast cancer in a population-based study,’ ‘High intakes of choline and betaine reduce breast cancer mortality in a population-based study,’ and ‘Common genetic polymorphisms affect the human requirement for the nutrient choline.’ If I can manage to upload this file, it’s nearly 50 pages of information. I hope some of you find it useful. Just fyi, from other threads on choline, I ultimately came to the conclusion that Jarrow’s Citicoline (I think I’m right in calling it an intermediate form of choline) was the supplement I wanted. My sister is now taking it and being hale and hearty in ways I am not (yet!) having no reactions whatsoever. I took ¼ capsule two days in a row and by the second, couldn’t sleep much at all—even with my usual crutches!! I’ll try again as I increase my MeB-12 and Folate levels… The very best to each of you.