Hello. Does anyone know how magnesium ties into pem and the recovery from it. I understand the basics.. Our mitochondria's produce atp via the cori or kreb's cycle. I try to keep my exercise somewhat aerobic in everything that I do. Elliptical machine mostly, or if I do venture off to the 5 lber's I always try to finish with a little bit of cardio in hopes that the kreb's cycle will handle the lactic acid better. I just don't understand where the magnesium comes into it all. Is the magnesium required during the repair of the damaged cells from the exercise? Is it used during cellular respiration during exercise? Can I prepare for these dips in magnesium that i get during these pem days? Should I preload my body so to speak with magnesium if I know I am going to have alot of physical activity? I have taken 4-5 times the normal amount for me of magnesium during this pem episode and this desensitized feeling just doesn't seem to level off. Very lethargic, fatigued but mostly numb. Another unusual thing that I believe is related to low magnesium is my low pulse throughout the day and while trying to exercise. I don't think I am able to clear any of the residual lactic acid out if I can't seem to get my heart rate up above 110? I guess just not as well. Ugh. This is discouraging. I spend all day reading this stuff and can't seem to remember any of it.. Damn.. Oh well, bear with me. I read "somewhere" that atp is recycled during our sleep. Would taking extra magnesium before I got to bed possibly help keep it from dropping? Has that helped anyone else? O.k.. My main concern is if oxidative stress has caused mitochondria's to be damaged. Or in some cases atp may be converted to adp?? at which point the mitochondrial part of the cell (or the entire cell??) wouldn't be recycled. I am wondering how long it takes to see some progress in repairing those. I take lots of efa's and 5 gms of phosphyatydial in the form of soy lecithin everyday. Does anyone know if there is an upper limit to taking the lecitin? With regards to taking b3, is 500 mg what a person should be shooting for with other b's of course. If I assume that an impaired ability to detox possibly can keep someone from essentially getting better in the sense that the excess free radicals can interfere enough with the mitochondrial regeneration to the point that there isn't any progress made? I don't know I am really fishing here but can't quite find an answer as to why I never seem to have any energy?? Well, if anyone has anything to add it would be greatly appreciated!! Thank You. Back to the medical insider website I suppose.. Thanks again.