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PEM experiment = COQ10 Any volunteers?

Discussion in 'Post-Exertional Malaise, Fatigue, and Crashes' started by lnester7, Jun 24, 2014.

  1. SDSue

    SDSue Florida

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    I looked into this but never pulled the trigger. As above, either I'm really low on CoQ10 or I have problems with uptake. So many describe heart palps at doses far below what I tolerate easily.

    Once again, I will donate my body (while I 'm still using it) to science and up that dose.
  2. Mij

    Mij Senior Member

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    thanks @SDSue we are taking the same form. I take the Life Extention brand with Kaneka. My levels were ok but not optimal when I was tested 10yrs ago. It's possible I don't need a higher dose in this case. I feel I do benefit from it though.
  3. Mij

    Mij Senior Member

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    Are you guys familiar with Shilajit? I'm looking into finding a pure form. It supposed to enhance the absorption of C0Q10. Interesting stuff.
  4. Mij

    Mij Senior Member

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    In reply to the topic of this thread. No, it does not help with PEM in my case, no supplement or drug has helped me with PEM.
  5. SDSue

    SDSue Florida

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    No clue on Shalajit? Do you have some good references?
  6. Mij

    Mij Senior Member

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  7. Hip

    Hip Senior Member

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    One thing I have found with Q10 is that you get greater benefits and effects from it if you take it with food, preferably with your main meal of the day.

    I suspect this is because Q10 facilitates the burning of fat in mitochondria, thus delivering more energy, and so if you have a good supply of fat from your meal, you will get more energy produced.
    taniaaust1, Gingergrrl and SDSue like this.
  8. Little Bluestem

    Little Bluestem Senescent on the Illinois prairie, USA

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    I have read that the biggest difference between ubiquinol and ubiquinone is that the ubiquinol reaches its peak blood level in about half the time of the ubiquinone. I take a ubiquine and a ubiquinone first thing in the morning, then I take another ubiquinone a couple of times later in the day.

    Recently, I cut back to just one more later in the day to save money, but my energy levels have gone down. I may try increase still more on days that I have to do more.

    My ubiqinol is Jarrow AH-absorb. My ubiquinone is Naure Made naturally orange CoQ10, which has no artificial colors or flavors, preservatives, starch, or gluten.
  9. Calathea

    Calathea Darkness therapy

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    I've just started playing with co-q10. I'm taking powder in capsules, so I know I should take it with oil. How much oil? Will a largeish Omega 3 capsule with every dose be enough?
  10. SpecialK82

    SpecialK82 Senior Member

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    Interesting. I just googled it and found that it could be messing with our blood pressure. Might what to monitor BP in any experiments with higher doses...

    "Some studies have shown that one to three months of CoQ-10 supplementation brings about a drop in blood pressure in hypertension patients. Mayo Clinic said there is a correlation between high blood pressure and low CoQ-10 levels in hypertension patients, but it is not yet understood whether the deficiency causes hypertension or vice versa."

    and.....

    "People with low blood pressure, diabetes or liver disease should not use CoQ-10 except under the guidance of a physician"
    Read more : http://www.ehow.com/about_5097809_benefits-coenzyme.html?ref=Track2&utm_source=ask
    taniaaust1 likes this.
  11. Calathea

    Calathea Darkness therapy

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    How about if the low blood pressure is being managed by medication (ivabradine)? I don't have access to the kind of doctor who would know anything about Co-Q10.
  12. Gingergrrl

    Gingergrrl Senior Member

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    @Calathea I have low blood pressure and my ND recommended that I take CoQ10 so I am not sure how it relates to BP? Also, my cardiologist keeps saying that Ivabradine is not available in the US and I can't figure out why?!
  13. Calathea

    Calathea Darkness therapy

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    Different drugs are available in different countries. I do isn't really know anything about ivabradine, it seems to be little used.

    I only see the cardiologist once, and he was pretty useless, apart from getting me on ivabradine and telling me to drink 3l of water a day. Pretty rude about ME, but hey, I will say one thing for him. He was good looking!

    I'm still hoping to get referred to Prof Julia Newton one day, but I've been trying for three years now. Meanwhile, I'm left to my own devices. I have an extremely vaguely-diagnosed mast cell disorder, and being on four meds for that has helped quite a bit.
  14. taniaaust1

    taniaaust1 Senior Member

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    Sth Australia
  15. Leopardtail

    Leopardtail Senior Member

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    Tanya,

    I can't remember, are you type I or type II diabetic?

    Leo
  16. SpecialK82

    SpecialK82 Senior Member

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    My good ME/CFS doc also knows that I have low blood pressure and has prescribed CoQ10, I have been taking it for a couple years.
  17. taniaaust1

    taniaaust1 Senior Member

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    I'll be type II . I was diagnosed with insulin resistance a couple of years ago but still had good sugar levels then, now though my sugar levels (according to my glucose monitor) are at diabetes level even with the very low carb diet the specialist put me on, but I havent got official diabetic diagnoses yet due to issues with getting to doctors and issues with getting to places for blood tests.
  18. Leopardtail

    Leopardtail Senior Member

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    Insulin resistance is known in ME, but not widely accepted. This causes hyperinsulinaemia, when you fix ATP production, the improvement in Insulin perormance creates a temporary risk of hypoglycaemia but only until the excess insulin is used up. For me it just meant the need to watch my BMs and eat ,more for a couple of days. You will need to watch yourself both with CoQ10 and with Ribose. The short answer though is that everything that makes you well, creates this risk, it's a part of the healing process you have to live with.

    Once the Insulin resistance resolves, things will likely improve markedly for you, less adrenal demand, less Insulin demand, better all in all...

    Your blood sugars won't be entirely due to Insulin resistance though (and you may not have it all), your high adrenalin levels will push blood sugars up and create demand for more Insulin.
  19. Leopardtail

    Leopardtail Senior Member

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    CoQ10 like vitamin D requires fat in to facilitate its absorption, hence it often coming in gelcaps.
    Hip likes this.
  20. Valentijn

    Valentijn Activity Level: 3

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    Have they checked you for any of the autoimmune or other markers of Type I Diatbetes? With the almost non-existent amount of carbs you get, it's shocking that your blood glucose rises much at all. But with Type I, glucose levels can still get high due to a sometimes extreme inability to produce insulin.

    It's also not always at the same level of severity. My fiance came down with Type I a couple years ago, and his need for insulin can fluctuate a lot, regardless of eating the same thing every day. Basically cells other than the Beta insulin-producing ones can be getting attacked in Type I to cause the diabetes, so the damage done isn't always necessarily permanent and/or consistent.
    Leopardtail likes this.

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