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Peckerman Revisited

Discussion in 'Latest ME/CFS Research' started by jimells, Jun 22, 2015.

  1. jimells

    jimells Senior Member

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    northern Maine
    In 2006 the UK Parliament Group on Scientific Research in ME (the Gibson Inquiry) held a series of public hearings to assess the progress (or lack) of ME research. This was a particularly interesting process because it included investigating the political and social environment we find ourselves stuck in. To me, it was what the "P2P" could have been if it had been convened by honest people.

    A group called "BRAME - Blue Ribbon for the Awareness of Myalgic Encephalomyelitis" submitted a review of important research papers, including Dr Peckerman's 2003 paper "Abnormal Impedance Cardiography Predicts Symptom Severity in CFS". I have posted the review of the paper in it's entirety, so it's rather lengthy.

    I've been thinking about this paper while reading about recent research by Fluge and Mella into endothelial dysfunction. I'm not qualified to analyze research papers, so I am very curious to find out if this paper has stood the test of time. Has there been any follow up at all in the past 12 years? Should there be?

    Does anyone know off hand if this research was included in either the P2P or the IOM evidence reviews? I vaguely recall that the P2P evidence review only included treatment trials. Apparently treatment does not require diagnosis.
     
  2. JaimeS

    JaimeS Senior Member

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    I'm glad they said it was unlikely to be due to deconditioning. When I did my exercise tolerance test at Mayo (no, I didn't do two; I didn't know you needed two at the time) they said that this was due to deconditioning. At that point, I'd been a full-time teacher just a few months before. I'm a lab instructor who literally never sat down. I said, "how long does it take to become deconditioned?" The tech didn't say anything, because he knew he didn't have a leg to stand on.

    Pun quite intended.

    From the doc's POV, a lot of our debility could be from deconditioning, so it's important to compare us to deconditioned controls whenever possible...

    -J
     
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  3. Gingergrrl

    Gingergrrl Senior Member

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    @jimells I do not know if this paper was included in P2P but I tried for months last year to find any sort of follow up on this study but couldn't find anything. I tried to locate Arnold Peckerman as well as the company who made the impedance Cardiography machines and literally went in circles until I gave up.
     
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  4. alex3619

    alex3619 Senior Member

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    Logan, Queensland, Australia
    This study has been quite well cited by others. Many of our experts are aware of it. I do not think that its ever properly been investigated as to mechanisms. It appears likely that this is a form a diastolic heart failure (not systolic which is what most docs are familiar with). In my opinion this could be due to either some form of cardiomyopathy or vascular issues. It could however be due to a lack of some proteins (epigenetic effects) or probably lots of other things. There is not enough research on these kinds of findings ... or much of any findings.

    I think, and this is anecdotal for now, some Stanford researchers are saying the heart is fine, but that the entire vascular system isn't The two are closely connected.

    So for right now we are left with lots of unanswered questions.
     
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  5. Sean

    Sean Senior Member

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    A very interesting idea.
     
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