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Patent For XMRV Test - WPI/Ruscetti

Discussion in 'XMRV Testing, Treatment and Transmission' started by shannah, Dec 28, 2010.

  1. shannah

    shannah Senior Member

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    Patent:DIAGNOSIS AND TREATMENT OF DISEASES OR DISORDERS ASSOCIATED WITH XENOTROPIC MURINE LEUKEMIA VIRUS
    .by XMRV Global Action on Tuesday, December 28, 2010 at 12:05pm.Patent application Published on 12/23/2010



    (WO/2010/148323) DIAGNOSIS AND TREATMENT OF DISEASES OR DISORDERS ASSOCIATED WITH XENOTROPIC MURINE LEUKEMIA VIRUS





    Pub. No.: WO/2010/148323 International Application No.: PCT/US2010/039208

    Publication Date: 23.12.2010 International Filing Date: 18.06.2010

    IPC: C12Q 1/70 (2006.01)



    Applicants: WHITTEMORE PETERSON INSTITUTE FOR NEURO-IMMUNE DISEASE [US/US]; 6600 N. Wingfield Parkway Sparks, Nevada 89436 (US) (All Except US).

    MIKOVITS, Judy, A. [US/US]; (US) (US Only).

    LOMBARDI, Vincent, C. [US/US]; (US) (US Only).

    RUSCETTI, Sandra, K. [US/US]; (US) (US Only).

    RUSCETTI, Francis, W. [US/US]; (US) (US Only).



    Inventors: MIKOVITS, Judy, A.; (US).

    LOMBARDI, Vincent, C.; (US).

    RUSCETTI, Sandra, K.; (US).

    RUSCETTI, Francis, W.; (US).



    Title: DIAGNOSIS AND TREATMENT OF DISEASES OR DISORDERS ASSOCIATED WITH XENOTROPIC MURINE LEUKEMIA VIRUS

    Abstract: <!-- if (drawingString != 'NULL') { self.document.writeln(drawingString); } else { self.document.writeln("") } // -->Methods of detecting, diagnosing, monitoring or managing an XMRV-related neuroimmune disease such as chronic fatigue syndrome or XMRV-related lymphoma such as mantle cell lymphoma in a subject are disclosed. These methods comprise determining presence, absence or quantity an XMRV immunopeptide, an XMRV antigen, or an XMRV nucleic acid in a sample from a subject. Therapeutic methods of treatment with anti-retroviral agents are also disclosed. Further disclosed are assays for testing compounds having activity against XMRV.





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  2. free at last

    free at last Senior Member

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  3. shannah

    shannah Senior Member

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  4. shannah

    shannah Senior Member

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    Thanks free at last.

    These documents are loaded with information. Here's the last entry from the link free at last posted:

    EXAMPLE 22: MXRV DETECTION IN SUBJECTS WITH CHRONIC LYME DISEASE

    [0274] This example demonstrates the presence of XMRV in subjects having chronic lyme disease. Methods are according to Examples 1-21 unless otherwise described.

    [0275] Samples from twenty subjects diagnosed with chronic lyme disease were tested for

    XMRV Patients with a diagnosis of Chronic lyme disease generally fit all of the criteria of Chronic fatigue syndrome.

    [0276] Results showed that XMRV was detected in 20/20 cases tested.
  5. shannah

    shannah Senior Member

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    On the last page of the PDF version, there's a Phylogenetic Tree of XMRV(P) & other gammaretroviruses as presented in the You Tube presentation from Norway.

    Can't seem to paste it over here though.
  6. August59

    August59 Daughters High School Graduation

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    Upstate SC, USA
  7. shannah

    shannah Senior Member

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    Reposted from another list with permission:

    "Based on reading this patent, it looks like the people at WPI have found XMRV in other diseases like Amyotrophic Lateral Sclerosis (Lou Gehrigs disease), and that there are subgroups of Parkinsons, Alzheimers, Bipolar Disorder that are XMRV-related.

    http://www.wipo.int/pctdb/en/wo.jsp?IA=US2010039208&DISPLAY=DESC

    I put some interesting Excerpts here:

    Here thet talk about making a vaccine to prevent XMRV related diseases:

    "[0133 ] The vaccine including an XMRV antigen, or a nucleic acid vector encoding an XMRV antigen, can confer immunity against XMRV-related Chronic Fatigue Syndrome (CFS), XMRV-related fibromyalgia, XMRV-related Multiple Sclerosis (MS), XMRV-related Parkinson's Disease, XMRV-related Amyotrophic Lateral Sclerosis (ALS), XMRV-related autism spectrum disorder (ASD), XMRV-related chronic lyme disease, XMRV-related Mantle Cell Lymphoma (MCL), or XMRV-related Chronic Lymphocytic Leukemia lymphoma (CLL)."

    Here is what they suggest for treatment (antiretrovirals and NF-kB inhibitors like Rituxan):

    0138] Also provided are anti-retroviral agents for treating an XMRV-related disease or disorder. For example, anti-retroviral agents can be used to treat an XMRV-related neuroimmune disease or an XMRV-related lymphoma. An anti-retroviral agent can be an anti-retroviral compound or pharmaceutical composition including an anti-retroviral compound. Examples of anti- retroviral agents that can be used to manage or treat an XMRV-related neuroimmune disease or an XMRV-related lymphoma include, but are not limited to, acyclovir, penciclovir (famciclovir), gancyclovir (ganciclovir), deoxyguanosine, foscarnet, idoxuridine, trifluorothymidine, vidarabine, sorivudine, zidovudine (AZT, ZVD, azidothyidine, e.g., Retrovir), didanosine (ddl, e.g., Videx and Videx EC), zalcitabine (ddC, dideoxycytidine, e.g., Hivid), lamivudine (3TC, e.g., Epivir), stavudine (d4T, e.g., Zerit and Zerit XR), abacavir (ABC, e.g., Ziagen), emtricitabine (FTC, e.g., Emtriva (formerly Coviracil)), entecavir (INN, e.g., Baraclude), apricitabine (ATC), tenofovir (tenofovir disoproxil fumarate, e.g., Viread), adefovir (bis-POM PMPA, e.g., Preveon and Hepsera), multinucleoside resistance A, multinucleoside resistance B, nevirapine (e.g., Viramune), delavirdine (e.g., Rescriptor), efavirenz (e.g., Sustiva and Stocrin), etravirine (e.g., Intelence), adefovir dipivoxil, indinavir, ritonavir (e.g., Norvir), saquinavir (e.g., Fortovase, Invirase), nelfinavir (e.g., Viracept), agenerase, lopinavir (e.g., Kaletra), atasanavir (e.g., Reyataz), fosamprenavir (e.g., Lexiva, Telzir), tipranavir (e.g., Aptivus), darunavir (e.g., Prezista), amprenavir, deoxycytosine triphosphate, lamivudine triphosphate, emticitabine triphosphate, adefovir diphosphate, penciclovir triphosphate, lobucavir triphosphate, amantadine, rimantadine, zanamiyir and oseltamivir, raltegravir (e.g., Isentress), elvitegravir (e.g., GS 9137 or JTK-303), MK-2048, maraviroc (e.g., Celsentri), enfuvirtide (e.g., Fuzeon), TNX-355, PRO 140, BMS-488043, plerixafor, epigallocatechin gallate, vicriviroc, aplaviroc, b12 (an antibody against HIV found in some long-term nonprogressors), griffithsin, DCM205, bevirimat, and vivecon. For example, one or more of AZT and cidofovir can be used to manage or treat an XMRV-related neuroimmune disease or an XMRV-related lymphoma. As another example, an interferon (e.g., interferon-β) can be used to manage or treat an XMRV-related neuroimmune disease or an XMRV-related lymphoma.
    [0139] As another example, an agent for treating an XMRV-related disease or disorder can target the immune response to the retrovirus, such as NfkB inhibitors and monoclonal antibodies targeting virally infected cells including, but not limited to, Rituxan and Velcade.

    Chronic Lyme Patients:
    20/20 tested positive for XMRV "
  8. leaves

    leaves Senior Member

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    Acyclovir is not an antiretroviral... Does it have activity against xmrv?
  9. Daffodil

    Daffodil Senior Member

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    i think they are just listing everything in case one day it might be shown to help lol

    can you imagine being annette whittemore? "i started an institute that cured CFS...oh yea...we also cured lyme, cancer, parkinsons, autism, ALS, MS, and mental illness too. what did you do?"

    LMAO
  10. ggingues

    ggingues $10 gift code at iHerb GAS343 of $40

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    Concord, NH
    Yes, that would be something else!
  11. shannah

    shannah Senior Member

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    Getting back to the very last page of this patent document again (85 pages), can one of our scientific minds here take a look at it. Apparently this is a phylogenetic tree and it lists 28 entries subdivided into different categories. Do you think this indicates that they've discovered 28 different variants of X and P ???? If not, what does it represent?

    http://www.wipo.int/pctdb/images4/PCT-PAGES/2010/512010/10148323/10148323.pdf

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