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Parkinson's disease, the gut, & the vagus nerve: Vagotomy and subsequent risk of Parkinson's disease

Discussion in 'Other Health News and Research' started by Bob, Jun 24, 2015.

  1. Bob

    Bob

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    England (south coast)
    I came across this on Twitter, via Erica Verrillo.

    News Article...

    Parkinson's disease may begin in the gut
    Parkinson's disease begins in the gastrointestinal tract, large study indicates
    June 23, 2015
    http://www.sciencedaily.com/releases/2015/06/150623103609.htm
    Read more:
    http://www.sciencedaily.com/releases/2015/06/150623103609.htm


    Research paper:

    Vagotomy and subsequent risk of Parkinson's disease
    Elisabeth Svensson, Erzsébet Horváth-Puhó, Reimar W Thomsen, Jens Christian Djurhuus, Lars Pedersen, Per Borghammer and Henrik Toft Sørensen
    Annals of Neurology
    29 MAY 2015
    DOI: 10.1002/ana.24448
    http://onlinelibrary.wiley.com/doi/10.1002/ana.24448/abstract
     
    Last edited: Jun 24, 2015
    maryb, Ecoclimber, ahmo and 4 others like this.
  2. Bob

    Bob

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    Last edited: Jun 24, 2015
    Never Give Up likes this.
  3. Ecoclimber

    Ecoclimber Senior Member

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    The media has been reporting back since 2009 that gut flora is the cause for MS, Obesity, Behavior, Mental illness, heart disease and just about every other disease known to mankind. Unfortuanately, there are 100 trillions microbes living in the intestinal tract.The permutations are astronomical given 500-1000 species and still more that have not been identified.

    This is a totally a new frontier, Microbiome. This is why the Microbiome Project was authorized by the NIH to the tune of $668 million dollars ( except for ME/CFS...the NIH just couldn't peal off a measly $1million for Lipkin's microbio project ) and spread across research institutes in the U.S. to identify possible causation with known diseases. I have not heard of serious consideration in targeting the gut flora in research projects for these diseases unless it is within the Microbiome Project but we are looking way down the road for any significant break throughs in my opinion.

    2010
    Biologists at the California Institute of Technology (Caltech) have demonstrated a connection between multiple sclerosis (MS) -- an autoimmune disorder that affects the brain and spinal cord -- and gut bacteria.
    http://www.sciencedaily.com/releases/2010/07/100719162643.htm

    2015
    http://www.express.co.uk/life-style...reat-Alzheimers-multiple-sclerosis-Parkinsons
     
    Last edited: Jun 25, 2015
    A.B. likes this.
  4. Hip

    Hip Senior Member

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    I wonder whether this reduction in Parkinson's incidence is due to the fact that the vagus nerve is the main route for carrying inflammatory signals from the body peripheries (like the gut) into the central nervous system (CNS), because in the CNS, these inflammatory signals trigger the release of pro-inflammatory cytokines from microglial cells in the brain.

    So if the vagus nerve is cut, these inflammatory signals from peripheral locations like the gut may not reach the brain, meaning that the overall level of inflammation in the brain may be reduced, especially in people with some mild chronic gut inflammation. This reduction of brain inflammation due to a cut vagus may conceivably be the factor that protects against the development of Parkinson's disease, as brain inflammation releases several toxic factors such as superoxide.



    I wonder what would happen if you performed a truncal vagotomy on an ME/CFS patient. Might cutting the vagus nerve in this way cure or improve ME/CFS? Michael VanElzakker thinks that inflammatory signals traveling along the vagus nerve to the brain are the cause of ME/CFS symptoms, by virtue of the fact that these inflammatory signals will ramp up brain inflammation and instigate sickness behavior.

    If VanElzakker's theory is right, then blocking these signals from traveling along the vagus could be an effective treatment for ME/CFS.

    I have often thought that using a local anesthetic (by injection) on the vagus, to temporarily block the inflammatory signals sent along this nerve, might be a very interesting experiment to perform on an ME/CFS patient. Would temporarily anesthetizing the vagus nerve, just like a dentist does to the nerves in your mouth, make ME/CFS symptoms disappear for a few hours?

    I can't imagine it would be difficult to anesthetize the vagus nerve. Provided the vagus nerve was only anesthetized below the heart (so that heart function is not affected), then I would think this should be safe. It would be like a temporary truncal vagotomy. If temporarily anesthetizing the vagus helped ME/CFS, then a permanentl truncal vagotomy might be considered.



    It would also be interesting to know if the incidence of ME/CFS is lower in patients that have had truncal vagotomy. If so, this would tend to indicate the involvement of the vagus nerve in generating ME/CFS symptoms.

    Dr John Chia has shown that 82% of all ME/CFS patients have a chronic enterovirus infection of the parietal cells of the stomach (the stomach acid-secreting cells). Now it just so happens that the vagus nerve is directly connected to these parietal cells (since the vagus helps activate these cells to release stomach acid). This chronic enterovirus infection could be sending inflammatory signals to the brain via the vagus, giving rise to the symptoms of ME/CFS.
     
    Last edited: Jun 25, 2015
  5. natasa778

    natasa778 Senior Member

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