The 12th Invest in ME Research Conference June, 2017, Part 2
MEMum presents the second article in a series of three about the recent 12th Invest In ME International Conference (IIMEC12) in London.
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Pariante - inflammation underlying treatment resistant depresssion

Discussion in 'Other Health News and Research' started by Marco, Aug 1, 2017.

  1. Marco

    Marco Grrrrrrr!

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    Near Cognac, France
    Hardly cutting edge but a reminder of the direction of travel in psychiatry.

    Credit where due to Carmine Pariante :

    How common Ibuprofen pills can treat your low mood

    Read more: http://www.dailymail.co.uk/health/a...n-pills-help-cure-low-mood.html#ixzz4oUDDQACz
     
  2. Sidereal

    Sidereal Senior Member

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    The headline made me chuckle. I recall sitting down for lunch with a colleague about 10 years ago, around the time a big study was published of relative uselessness of SSRIs in treatment-resistant cases. I remember remarking that maybe what they need is ibuprofen, not more psych meds and she said nothing, just looked at me as if I'd said the dumbest thing ever. :woot:
     
    Helen, echobravo, Marco and 2 others like this.
  3. Sean

    Sean Senior Member

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    Shock! Horror!

    At least some of what we currently label 'mental' illness, might actually be driven by biological mechanisms.
     
  4. Woolie

    Woolie Senior Member

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    This research is really a mess.

    Depression is generally measured in these studies using self-report scales. These scales include three distinct types of items:
    - affective items (questions about your mood and feelings, like whether you feel sad often)
    - cognitive items (questions about whether you feel hopeless about the future, bad about yourself, etc.)
    - "somatic" or "physiological" items (questions about whether you're tired, have trouble concentrating or trouble sleeping).

    Only one set of items significantly improves with anti-inflammatory treatment. Can you guess which one? Yep, its the "somatic" or "physiological" items.

    It is very likely that the somatic/physiological items, which are included in self-report scales for prgramtic resasons (they tend to correlate with the "real" depression items), are measuring a lot of things other than depression, and it is these that respond to ant-inflammatories.

    What a mess we have got ourselves into with depression, eh!
     

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