The body is said to have a "triage" system for distribution, or maybe utilization of, b12 and folate. Healing can turn on with methylation and ATP startup and yet deficiency symptoms can worsen on other layers. The placement of edema within a layer can be done by the symptoms set it responds with; angular cheilitis, IBS and acne type lesions, and others, depending upon duration and severity of insufficiency. For me the comings and goings of edema were very mysterious without a framework. It came and went at various times in my life. Five years of watching the comings and goings of paradoxical folate insufficiency it became clear that the first symptom to appear was edema and evidenced by weight gain. It was also the first symptom to clearly reverse upon a sufficient dose of Metafolin. This was after all other nutrients were in place including the Deadlock Quartet of AdoCbl, MeCbl, L-methylfolate and L-carnitine fumarate; basic vitamins and minerals, fats etc. I ran into trouble when my diuretic started working too well. It turns out I didn't need it at all any more. I was out of folate insufficiency by that time about 3 weeks a month, enough to take the water off. Just these past months after reducing B1, B2 and B3 to what was in a moderately low dose b-complex twice a day I have been consistently out of folate insufficiency for months now. It's a delicate balance all the way around. Edema appears to be a more sensitive indicator to me than angular cheilitis for folate insufficiency, being obvious 2 days sooner. Reading around the forums here edema is mentioned with some frequency and ascribed to all sorts of causes, who knows how many of them correct or maybe correctable. After decades I had never thought that it was correctable. Have any others had the end of edema with the end of folate insufficiency or turning on and off with other symptoms?