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Pandemrix Vaccine, Autoimmune Reaction, & Narcolepsy

Discussion in 'Other Health News and Research' started by Gemini, Jul 12, 2015.

  1. Gemini

    Gemini Senior Member

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    Pandemrix vaccine triggers antibodies that bind to hypocretin receptor 2 causing an autoimmune reaction leading to narcoplesy in genetically predisposed people...

    "Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2"
    http://www.ncbi.nlm.nih.gov/pubmed/26136476

    There have been past posts on this topic, perhaps @Jonathan Edwards might comment on these new & intriguing findings?

    Researchers are exploring if somehow unblocking the brain's receptor might allow the hypocretin system to recover...and how to make vaccines safer by removing the specific region of the protein that mimics the receptor.
    "Narcoplesy link to pandemic flu vaccine becomes clearer," Science, 3 July 2015
    http://www.ncbi.nlm.nih.gov/pubmed/26138959

    Edit: To add Science link
     
    Last edited: Jul 13, 2015
    natasa778, Simon, Valentijn and 2 others like this.
  2. Valentijn

    Valentijn Senior Member

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    They've associated it with the HLA-DQB1*06:02 haplotype.
     
  3. natasa778

    natasa778 Senior Member

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    Whaaaa, a vaccine-induced 'durable antibody responses' triggering a debilitating, life-long brain disorder? This cannot be so. This mustn't be!
     
    Sidereal and geraldt52 like this.
  4. natasa778

    natasa778 Senior Member

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    uh huh

    http://www.hindawi.com/journals/aurt/2014/242048/
     
    geraldt52 likes this.
  5. Gemini

    Gemini Senior Member

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    Mentioned in the Science article is whether the virus itself--H1N1 or other influenza strains--can trigger narcolepsy.

    Apparently cases increased in China after the 2009 pandemic where the vaccine wasn't used & researchers have found serum from some patients does bind to the hypocretin receptor.

    Hope we hear more about this...
     
    Valentijn likes this.

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