Review: 'Through the Shadowlands’ describes Julie Rehmeyer's ME/CFS Odyssey
I should note at the outset that this review is based on an audio version of the galleys and the epilogue from the finished work. Julie Rehmeyer sent me the final version as a PDF, but for some reason my text to voice software (Kurzweil) had issues with it. I understand that it is...
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Palmitoylethanolamide (PEA) and Leptin Sensitivity.

Discussion in 'Antivirals, Antibiotics and Immune Modulators' started by Ema, Mar 22, 2015.

  1. Ema

    Ema Senior Member

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    So not only good for dampening microglial inflammation...but might also help with weight issues. At least in female, obese, menopausal rats...

    Palmitoylethanolamide prevents metabolic alterations and restores leptin sensitivity in ovariectomized rats.

    Authors
    Mattace Raso G1, Santoro A, Russo R, Simeoli R, Paciello O, Di Carlo C, Diano S, Calignano A, Meli R.
    Author information
    Journal
    Endocrinology. 2014 Apr;155(4):1291-301. doi: 10.1210/en.2013-1823. Epub 2014 Jan 15.

    Affiliation
    Abstract

    It has been suggested a role of fatty acid ethanolamides in control of feeding behavior. Among these, palmitoylethanolamide (PEA) has not been directly implicated in appetite regulation and weight gain. The aim of this study was to investigate the effect of PEA on food intake and body weight and the interaction between PEA and hypothalamic leptin signaling in ovariectomized rats. Ovariectomy produced hyperphagia and increased weight gain, making it an useful model of mild obesity. Ovariectomized rats were treated with PEA (30 mg/kg sc) for 5 weeks. Then, blood was collected, and hypothalamus and adipose tissue were removed for histological, cellular, and molecular measurements. We showed that PEA caused a reduction of food intake, body weight, and fat mass. The mechanisms underlying PEA effects involved an improvement in hypothalamic leptin signaling, through a raise in signal transducer and activator of transcription 3 phosphorylation. We also reported that PEA reduced AMP-activated protein kinase-α phosphorylation and modulated transcription of anorectic and orexigenic neuropeptides in the hypothalamus. Moreover, PEA increased AMP-activated protein kinase-α phosphorylation and carnitine palmitoyltransferase 1 transcription in adipose tissue, suggesting an increase in ATP-producing catabolic pathway. PEA also polarized adipose tissue macrophages to M2 lean phenotype, associated to a reduction of inflammatory cytokines/adipokines. To demonstrate the direct effect of PEA on leptin sensitivity without interference of adiposity loss, we obtained consistent data in PEA-treated sham-operated animals and in vitro in SH-SY5Y neuroblastoma cell line. Therefore, our data provide a rationale for the therapeutic use of PEA in obese postmenopausal woman.

    PMID
    24428531 [PubMed - indexed for MEDLINE]
    Atypon: Full text
     
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  2. Jammy88

    Jammy88 Senior Member

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    I take it, as suggested by my neurologist. Great supplement! :)
     
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  3. anniekim

    anniekim Senior Member

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    @Jammy88 may I ask what dose you take and how you feel it helps symptoms wise? Is it the Peapure supplement you take? Many thanks
     
  4. Jammy88

    Jammy88 Senior Member

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    @anniekim , I buy it on PeaVera.com and I take 2-3 capsules a day, depending on how I feel. Each capsule is 400mg.
    It mainly eases my neurological symptoms (paresthesias, etc). It's also indicated to ease fibromyalgic pain.
     
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  5. anniekim

    anniekim Senior Member

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    Thanks @Jammy88. I have just ordered some and will see if it helps. I ordered it from the Dutch site, can't order to UK from Italian site, shame as 50 euros cheaper for a six pack! On the Dutch website it says after three months you can reduce the dosage, I take it you find you need to continue on 2-3 caps? Many thanks
     
    Last edited: Mar 24, 2015
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  6. Jammy88

    Jammy88 Senior Member

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    I started taking it in October and have been pretty constant for the first 3-4 months. Now I take it a bit less frequently, so yes I guess what is said on the website is correct. :) Then I believe it depends on the person.
    I think PEA will help you with neuromuscular pain, as it is very effective in reducing neuroinflammation - which is a very common issue for the all of us on PR.

    Best wishes and keep us posted!
     
    anniekim likes this.
  7. anniekim

    anniekim Senior Member

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    Thanks @Jammy88 I will certainly let you know how I respond to it. I have a lot of neuro pain so will be interesting to see if it helps
     
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  8. EtherSpin

    EtherSpin Senior Member

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    anyone still on this ? wondering where you are in the world - Im in Australia and even if it was available to order in (probably?) its going to be costly to try as the Aussie dollar is so bad VS the Euro and the tablets are almost a Euro each :)
     
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  9. Ema

    Ema Senior Member

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    Looks like a new version is set to come out in 2016 called PeaPlex.

    Anyone have any ideas what is new about this version?
     
    Kina likes this.

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