I am suffering from pain. It is mostly located in my legs (muscles, feels like lactic acid) and in my arms. If I use my hands and arms to read a book, use my laptop, or something else and it burns, and my joints eventually makes strange cracking sounds, especially when i stretch them out. I also suffer from pain in my legs. Walking or standing still a few minutes can lead to muscle tension or cramps which also hurts. The pain in my arms is my biggest issue. Burning and joint cracking are key words that describe my pain. I can reduce it by not using my hands at all, but that seems like a boring life. I have seen a rheumatologist who ruled out R.A. I showed him my joint cracking, and he said it was normal, but he couldn't say much more than that. I have tried Ibuprofen, Paracetamol, Tramadol, Diflofenac and Amitriptilin. They do not help, except for the latter one, but it made me extremely tired, even after 4 weeks, so i quit it. If I take 100mg of tramadol instant release _before_ I do stuff that can lead to pain it helps somewhat. I told my doc this and she gave me OxyNorm instant release (oxycodone) 10 mg. I have been using 15 tablets a month for the last half year. The capsules gives pain relief for 4 hours. It has been working pretty alright, but my pain is increasing from month to month. It is also hard to know when I need to take one capsule or not. My doc says that I need to take a capsule whenever I feel that my pain is increasing. Sometimes my pain is increasing, but after an hour or so it can almost vanish. Other times it only gets worse and worse, and by the time I've taken it I am in extreme pain, and even with 10 mg Oxycodone it isn't sufficient to take more than say 50% of the pain away. Is anyone in a similar situation? Say I've used Oxycodone 10mg instant release for every other day the last 4 months. Could that make tolerant, or is my dosage too low, and is the half-life so short that it is impossible? What drugs are available? Has anyone tried Palexia/Nycunta (tapentadol)? It is supposed to be a better, and more potent than Tramadol. Could an opiod rotation work out if I am indeed tolerant to Oxycodone? I also know that Buprenorphine (norspan patch) is available. I do not know if my pain enough is serious enough for the doctor to consider it. I do not like the idea of having an opioid in my blood 24/7. I need to be able to drive my car, and I also use zopiclone for sleep. The idea of being somewhat sedated all day long scares me. OxyContin is also an option, but I don't want to end up like a junkie. I hope anyone has some experiences to share with me. I am going to my GP on Thursday to discuss this. I will also discuss whether she agrees that I should be referred to the pain clinic at the hospital.