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PACE Trial summaries/critiques/links thread - no discussion please

Discussion in 'Latest ME/CFS Research' started by Dolphin, Jan 10, 2012.

  1. Dolphin

    Dolphin Senior Member

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    I thought I'd set up this thread, as a lot of interesting points have been made on the PACE Trial but they have been buried in the PACE Trial mega-thread http://forums.phoenixrising.me/showthread.php?4926-PACE-Trial-and-PACE-Trial-Protocol .

    So this is a thread where people can go to find information more easily.

    I think discussion should be kept off it as much as possible to keep it "clean" - if people want to discuss anything in it, (including whether such a piece should be added if they have doubts) they can do so in the mega-thread: http://forums.phoenixrising.me/showthread.php?4926-PACE-Trial-and-PACE-Trial-Protocol

    So what I think should go here are pieces that have already taken a bit of work rather than new pieces written for this thread e.g. letters submitted on the topic, links to websites, summary pieces, etc.
     
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  2. Dolphin

    Dolphin Senior Member

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  3. Esther12

    Esther12 Senior Member

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    This is the best concise summary I've seen so far. It misses a lot out... but otherwise it would be over 150 pages.

    "Methodological Inconsistencies in the PACE trial for ME/CFS" by Tate Mitchell

    edited to remove a link which doesn't work, there's a plain text version (graphs linked to at the end) at:

    https://listserv.nodak.edu/cgi-bin/wa.exe?A2=ind1112A&L=CO-CURE&P=R540&I=-3

    I've been trying to attach a fuller version beneath, but having trouble! The version above can easily be copied and pasted in to a word file (I find listserv a bit of a pain to read).
     
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  4. Dolphin

    Dolphin Senior Member

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    Letter published in the June 2011 issue of the Psychologist magazine

    Letter published in the June 2011 issue of the Psychologist magazine

     
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  5. Esther12

    Esther12 Senior Member

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    There is a section (section 6) on the reporting of harms in the PACE Trial in:
    Kindlon T. Reporting of Harms Associated with Graded Exercise Therapy and Cognitive Behavioural Therapy in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Bulletin of the IACFS/ME. 2011;19(2):59-111.

    http://www.iacfsme.org/LinkClick.aspx?fileticket=Rd2tIJ0oHqk=&tabid=501
     
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  6. Esther12

    Esther12 Senior Member

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  7. Dolphin

    Dolphin Senior Member

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    Neither link works for me at the moment. Here's the plain text link:
    https://listserv.nodak.edu/cgi-bin/wa.exe?A2=ind1112A&L=CO-CURE&P=R540&I=-3 .
     
  8. Battery Muncher

    Battery Muncher Senior Member

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  9. Dolphin

    Dolphin Senior Member

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  10. Dolphin

    Dolphin Senior Member

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    6 letters were published in Psychological Medicine following this paper:

    have been collated here: http://www.meassociation.org.uk/201...ournal-of-psychological-medicine-august-2013/

    ---

    Unpublished letter by Tom Kindlon is on PubMed Commons: http://www.ncbi.nlm.nih.gov/pubmed/23363640#cm23363640_751
     
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  11. Dolphin

    Dolphin Senior Member

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  12. Dolphin

    Dolphin Senior Member

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    Not open access
     
  13. Dolphin

    Dolphin Senior Member

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    Not open access

     
  14. Dolphin

    Dolphin Senior Member

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    Published responses to:

    ---

     
    Last edited: Nov 21, 2015
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  15. Dolphin

    Dolphin Senior Member

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    http://www.bmj.com/content/350/bmj.h227/rr-10

     
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  16. Dolphin

    Dolphin Senior Member

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    Here's a list of PACE Trial papers
    (copied from Bob's post):

    Updated December 2015.

    ------------------------------------------------------------------------------------------------------

    2007 Published protocol:
    White PD, Sharpe MC, Chalder T, DeCesare JC, Walwyn R; PACE trial group.
    Protocol for the PACE trial: a randomised controlled trial of adaptive pacing, cognitive behaviour therapy, and graded exercise, as supplements to standardised specialist medical care versus standardised specialist medical care alone for patients with the chronic fatigue syndrome/myalgic encephalomyelitis or encephalopathy.
    BMC Neurol. 2007; 7:6.
    http://www.biomedcentral.com/1471-2377/7/6

    2011 Main PACE trial paper:
    White PD, Goldsmith KA, Johnson AL, Potts L, Walwyn R, DeCesare JC, Baber HL, Burgess M, Clark LV, Cox DL, Bavinton J, Angus BJ, Murphy G, Murphy M, O'Dowd H, Wilks D, McCrone P, Chalder T, Sharpe M; PACE trial management group.
    Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial.
    Lancet. 2011; 377:823-36.
    http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(11)60096-2/abstract

    2012 Cost-effectiveness analysis (Includes employment and welfare benefits data):
    McCrone P, Sharpe M, Chalder T, Knapp M, Johnson AL, Goldsmith KA, White PD.
    Adaptive pacing, cognitive behaviour therapy, graded exercise, and specialist medical care for chronic fatigue syndrome: A cost-effectiveness analysis.
    PLoS ONE 2012; 7:e40808.
    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0040808

    2013 [Alleged] "Recovery" paper:
    White PD, Johnson AL, Goldsmith K, Chalder T, Sharpe MC.
    Recovery from chronic fatigue syndrome after treatments given in the PACE trial.
    Psychological Medicine 2013; 43:2227-35.
    http://journals.cambridge.org/abstract_S0033291713000020

    2013 Statistical Analysis Plan:
    Walwyn R, Potts L, McCrone P, Johnson AL, DeCesare JC, Baber H, Goldsmith K, Sharpe M, Chalder T, White PD.
    A randomised trial of adaptive pacing therapy, cognitive behaviour therapy, graded exercise, and specialist medical care for chronic fatigue syndrome (PACE): statistical analysis plan.
    Trials 2013; 14:386.
    http://www.trialsjournal.com/content/14/1/386

    2014 Adverse events and deterioration:
    Dougall D, Johnson A, Goldsmith K, Sharpe M, Angus B, Chalder T, White P.
    Adverse events and deterioration reported by participants in the PACE trial of therapies for chronic fatigue syndrome.
    J Psychosom Res. 2014; 77:20-6.
    http://www.sciencedirect.com/science/article/pii/S0022399914001883

    2015 Secondary Mediation Analysis (contains the step test results - graph only):
    Rehabilitative therapies for chronic fatigue syndrome: a secondary mediation analysis of the PACE trial.
    Chalder T, Goldsmith KA, White PD, Sharpe M, Pickles AR.
    Lancet Psychiatry 2015; 2:141–52
    http://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(14)00069-8/abstract

    2015 Two Year Follow Up:
    Sharpe M, Goldsmith KA, Johnson AL, Chalder T, Walker J, White PD.
    Rehabilitative treatments for chronic fatigue syndrome: long-term follow-up from the PACE trial.
    Lancet Psychiatry 2015; 2:1067–74
    DOI: http://dx.doi.org/10.1016/S2215-0366(15)00317-X
    http://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(15)00317-X/fulltext


    2015 Longitudinal Mediation Analysis - conference abstract only:
    Goldsmith K, Chalder T, White P, Sharpe M, Pickles A.
    Longitudinal mediation in the PACE randomised clinical trial of rehabilitative treatments for chronic fatigue syndrome: modelling and design considerations
    Trials 2015; 16(Suppl 2):O43 doi:10.1186/1745-6215-16-S2-O43
    http://www.trialsjournal.com/content/16/S2/O43


    ------------------------------------------------------------------------------------------------------


    Minor papers and PACE-related papers:

    Lawn T, Kumar P, Knight B, Sharpe M, White PD. (2010)
    Psychiatric misdiagnoses in patients with chronic fatigue syndrome.
    JRSM Short Rep. 1:28.

    Cella M, Sharpe M, Chalder T. (2011)
    Measuring disability in patients with chronic fatigue syndrome: reliability and validity of the Work and Social Adjustment Scale.
    J Psychosom Res. 71:124-8.

    Cella M, White PD, Sharpe M, Chalder T. (2013)
    Cognitions, behaviours and co-morbid psychiatric diagnoses in patients with chronic fatigue syndrome.
    Psychological Medicine 43:375-380. doi:10.1017/S0033291712000979

    Bourke JH, Johnson AL, Sharpe M, Chalder T, White PD. (2014)
    Pain in chronic fatigue syndrome; response to rehabilitative treatments in the PACE trial.
    Psychological Medicine 44:1545-52. doi:10.1017/S0033291713002201

    Cox D, Burgess M, Chalder T, Sharpe M, White P, Clark L. (2013)
    Training, supervision and therapists' adherence to manual-based therapy.
    International Journal of Therapy and Rehabilitation 20:180-186.

    White PD, Chalder T, Sharpe M. (2015)
    The planning, implementation and publication of a complex intervention trial for chronic fatigue syndrome: the PACE trial.
    BJPsych Bull. 39:24-7. doi: 10.1192/pb.bp.113.045005
    http://www.ncbi.nlm.nih.gov/pubmed/26191420
     
  17. Dolphin

    Dolphin Senior Member

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  18. Esther12

    Esther12 Senior Member

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    This thread should be updated... we don't have even have Tuller in here!

    Tuller's first PACE pieces (there are more if you look):

    http://www.virology.ws/2015/10/21/trial-by-error-i/
    http://www.virology.ws/2015/10/22/trial-by-error-ii/
    http://www.virology.ws/2015/10/23/trial-by-error-iii/

    Tuller Virology podcast: http://www.microbe.tv/twiv/twiv-397/

    The Goldin Sense About Statistics piece that focuses on problems with the trial's statistics and recovery claims:

    http://www.stats.org/pace-research-sparked-patient-rebellion-challenged-medicine/
     
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  19. A.B.

    A.B. Senior Member

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