My doctor started me on P5P after reviewing my 23andMe results along with some labs. She also started me on methyl b12 injections, Choline, Adeno b12 and I've been on Niacin for 2 years. I introduce things one at a time so started with the injections. After a week, added choline which made me extremely nauseous so stopped. Then the P5P. Around the time I started P5P, my symptoms got significantly worse and I developed eye strain. My body aches got so extreme that I couldn't sit at my desk comfortably and my fatigue and brain fog got much worse. It could have been a crash but I decided to stop all supplements. I felt significantly better the first day and it's day 3 and still feeling a bit better. My doctor thinks the P5P caused bad side effects. I wondered if anyone else had this experience? Also, I've been reading about T3 and T4 for ME and how it can really improve symptoms even for those with normal levels. I was given it years ago when I was being treated for Lyme disease and I felt HUGELY better - it gave me incredible energy. But the doctor who took over that care refused to give me more and I haven't thought to ask my ME doctor for it. But after reading some posts on it, I think it seems worth asking. Has anyone got experience with taking those?