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P450, 5AR, aromatase, things that affect hormone levels

Discussion in 'Hormones' started by triffid113, Aug 24, 2013.

  1. triffid113

    triffid113 Day of the Square Peg

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    Michigan
    I just want to start a topic about hormone levels and how to affect them via 5-alpha-reductase inhibitors, aromatase inhibitors, and P450 CYP up and down regulators. I'm out of time right now so I will just put in a starter, nothing major. But I am very interested in the topic of P450 and how it can be used. I see now people are patenting simply reading and applying this info (which I think should be illegal because it's like patenting part of the multiplication table). But anyway here's the study that made me want to start the topic:


    J Herb Pharmacother. 2005;5(1):17-26.

    A preliminary investigation of the enzymatic inhibition of 5alpha-reduction and growth of prostatic carcinoma cell line LNCap-FGC by natural astaxanthin and Saw Palmetto lipid extract in vitro.

    Anderson ML.

    Source

    Research and Development, Triarco Industries, Wayne, NJ 07470, USA. mark.anderson@triarco.com

    Abstract

    Inhibition of 5alpha-reductase has been reported to decrease the symptoms of benign prostate hyperplasia (BPH) and possibly inhibit or help treat prostate cancer. Saw Palmetto berry lipid extract (SPLE) is reported to inhibit 5alpha-reductase and decrease the clinical symptoms of BPH. Epidemiologic studies report that carotenoids such as lycopene may inhibit prostate cancer. In this investigation the effect of the carotenoid astaxanthin, and SPLE were examined for their effect on 5alpha-reductase inhibition as well as the growth of prostatic carcinoma cells in vitro. These studies support patent #6,277,417 B1. The results show astaxanthin demonstrated 98% inhibition of 5alpha-reductase at 300 microg/mL in vitro. Alphastat, the combination of astaxanthin and SPLE, showed a 20% greater inhibition of 5alpha-reductase than SPLE alone n vitro. A nine day treatment of prostatic carcinoma cells with astaxanthin in vitro produced a 24% decrease in growth at 0.1 mcg/mL and a 38% decrease at 0.01 mcg/mL. SPLE showed a 34% decrease at 0.1 mcg/mL.

    CONCLUSIONS:

    Low levels of carotenoid astaxanthin inhibit 5alpha-reductase and decrease the growth of human prostatic cancer cells in vitro. Astaxanthin added to SPLE shows greater inhibition of 5alpha-reductase than SPLE alone in vitro.
     

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