oxidative stress in cfs/me seems to be a common abnormality and the methylation protocols seem to be popular at trying to raise glutathione, our bodies main antioxidant with methyl b12 and methyl folate. What i wont to know is what role to other antioxidants play, specifically q10, al-carnitine, vit e and c and NAC(although seems debatable with folate absorption. But i would think using these other antioxidants would help reduce the need for glutathione raising supps or enhance these methyl supps. I have been taking these supps for quite sometime and cant say i have noticed any real improvement in cfs symptoms but maybe they are helping me to hold my current level of function as well has having other positive effects on our health. I mainly take these supps as they have quite good science to back them up. In reality the only things i have found to have a noticable effect on cfs symptoms are sleep meds, av's and immmune modulator cycloferron. All these treatments add up financially and im looking at trying to save money and use these that give the best bang for my buck. I would be interested to know others opinions on this. cheers!!!