- Messages
- 80
It would seem to me that the following is rather on point:
Antioxid Redox Signal. 2010 Jan;12(1):1-13.
Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria.
Kimura Y, Goto Y, Kimura H.
Source
Department of Molecular Genetics, National Institute of Neuroscience, Kodaira, Tokyo, Japan. kimura@ncnp.go.jp
Abstract
Hydrogen sulfide (H(2)S) is a synaptic modulator as well as a neuroprotectant in the brain. We recently showed that H(2)S protects neurons from oxidative stress by increasing the levels of glutathione (GSH), a major cellular antioxidant, by more than twice that of a control through enhancing the cystine transport. Here we show that H(2)S enhances the transport of cysteine to increase GSH production more than cystine transport and to redistribute the localization of GSH to mitochondria. The efficiency of GSH production enhanced by H(2)S is even greater by fourfold under oxidative stress by glutamate. H(2)S reinstated GSH levels in the fetal brain decreased by ischemia/reperfusion in utero. In addition, Neuro2a cells expressing a mitochondrial H(2)S-producing enzyme, 3-mercaptopyruvate sulfurtransferase (3MST), along with cysteine aminotransferase (CAT), showed significant resistance to oxidative stress. The present study shows that H(2)S protects cells from oxidative stress by two mechanisms. It enhances the production of GSH by enhancing cystine/cysteine transporters and redistributes GSH to mitochondria. H(2)S produced in mitochondria also may directly suppress oxidative stress. It provides a new mechanism of neuroprotection from oxidative stress by H(2)S.
----------
As you can see from the above, hydrogen sulfide plays an important role in the production and distribution of glutathione in the brain and in the control of oxidative stress.
I proposed that hydrogen sulfide plays a key role in CFS through the mitochondria and oxidative stress several years ago. This was confirmed by the work Rich referenced above. From my quick perusal, Dr. Golomb does not mention hydrogen sulfide (please correct me if I am wrong), but I think it is only a matter of time before we begin to see a fuller picture emerge, and my hunch is that it will include hydrogen sulfide.
Marian
Antioxid Redox Signal. 2010 Jan;12(1):1-13.
Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria.
Kimura Y, Goto Y, Kimura H.
Source
Department of Molecular Genetics, National Institute of Neuroscience, Kodaira, Tokyo, Japan. kimura@ncnp.go.jp
Abstract
Hydrogen sulfide (H(2)S) is a synaptic modulator as well as a neuroprotectant in the brain. We recently showed that H(2)S protects neurons from oxidative stress by increasing the levels of glutathione (GSH), a major cellular antioxidant, by more than twice that of a control through enhancing the cystine transport. Here we show that H(2)S enhances the transport of cysteine to increase GSH production more than cystine transport and to redistribute the localization of GSH to mitochondria. The efficiency of GSH production enhanced by H(2)S is even greater by fourfold under oxidative stress by glutamate. H(2)S reinstated GSH levels in the fetal brain decreased by ischemia/reperfusion in utero. In addition, Neuro2a cells expressing a mitochondrial H(2)S-producing enzyme, 3-mercaptopyruvate sulfurtransferase (3MST), along with cysteine aminotransferase (CAT), showed significant resistance to oxidative stress. The present study shows that H(2)S protects cells from oxidative stress by two mechanisms. It enhances the production of GSH by enhancing cystine/cysteine transporters and redistributes GSH to mitochondria. H(2)S produced in mitochondria also may directly suppress oxidative stress. It provides a new mechanism of neuroprotection from oxidative stress by H(2)S.
----------
As you can see from the above, hydrogen sulfide plays an important role in the production and distribution of glutathione in the brain and in the control of oxidative stress.
I proposed that hydrogen sulfide plays a key role in CFS through the mitochondria and oxidative stress several years ago. This was confirmed by the work Rich referenced above. From my quick perusal, Dr. Golomb does not mention hydrogen sulfide (please correct me if I am wrong), but I think it is only a matter of time before we begin to see a fuller picture emerge, and my hunch is that it will include hydrogen sulfide.
Marian