This is a very interesting paper which I would urge everyone to read. Currently it appears on Nature Precedings as a pre-publication manuscript (to stimulate discussion etc). I can only hope it is subsequently published. While written from the perspective of Gulf War Illness, she proposes similar physiological processes underlying a range of 'overlap' illnesses with non-specific and protean symptoms including ME/CFS. Predisposition to oxidative stress, stressor triggers, inflammation/oxidative stress, mitochondrial dysfunction etc will be very familiar I'm sure. http://precedings.nature.com/documents/6847/version/1/files/npre20126847-1.pdf While this may at first sight appear to be a slightly controversial 'think piece', Beatrice Golomb is a very experienced researcher and 'mainstream' as evidenced by her CV : http://cnl.salk.edu/~bgolomb/ It would be great to get her 'onboard' with ME/CFS research.