Hello all, I've managed to get my 23andme results before the FDA ordered 23andme to stop offering new customers health-related genetic results. I ran the raw data through : Genetic Genie, Promethease and MTHFR support. My homozygous (+/+) mutations are : MAO-A R297R ACAT1-02 MTRR A66G My hetorozygous (+/-) mutations are : VDR Bsm VDR Taq MTRR A664A BHMT-08 CBS A360A I also have an heterozygous (+/-) mutation of the MTHFR C677T. I've looked at : http://www.heartfixer.com/AMRI-Nutrigenomics.htm as well as the Phoenix Rising forums and this place : http://www.knowyourgenetics.com/ and completed the Methylation Pathway Analysis. I've read concerns over possible hypokalemia through re-opening certain pathways - it's not clear to me how frequent this is and which pathway are more likely to bring this about. Also, it's not clear whether Dr. Amy Yasko has raised this concern about serum potassium values dropping into hypokalemia range - which if accurate, is a significant concern. Much of the confusion also arises from the many protocols available and where to find the most up-to-date versions of each and whether any of those protocols have proven more effective relative to one another. Like any protocol meant to address any disease processes, it implies a trial & error period - that's a given. That being said, I've found the process of «getting started» with addressing my genetic weaknesses to be just overwhelming, because of the lack of clarity as to what one should do. Now, Dr. Yasko provides a step-by-step guide (NRI link above) as to what should be addressed first and so on and so forth. If there were no debate over her protocol, things wouldn't be so overwhelmingly difficult, but as things stand, there exists other protocols and some debate over which to use. I've also come across two «simplified protocols» one from Dr. Yasko and IIRC the second one from the late Rich Van Konynenburg (God rest his soul). Another relevant issue is : what's been the success rate of these various protocols thus far ? That said, I also take into account the multifaceted aspect of many disease processes. Worded differently, addressing methylation alone might not prove to be sufficient for many with CFS. For the sake of clarification, I haven't been diagnosed with CFS/FM. However, I've been formally diagnosed with : ADHD and OCPD. There's been many such posts on here calling for help in making sense of the above mentioned issues. I'd be grateful if anyone with in-depth knowledge of the subject of nutrigenomics would be so kind as to help me make more sense of it all. Take care.