Hi all, I'm not sure if this is the best place to post but I figured I'd give it a shot. I have had wonderful improvement through supporting methylation with a variety of supplements. However, even at low doses and careful balancing, anything that makes me feel truly better (better mood, more social, more energy, more endurance, etc.) comes at the cost of overstimulation, panic and sweating. Could this be as simple as histamine release in response to inflammation (need to take care of inflammation before supporting methylation)? Any help would be much appreciated. Thank you all.