The power and pitfalls of omics part 2: epigenomics, transcriptomics and ME/CFS
Simon McGrath concludes his blog about the remarkable Prof George Davey Smith's smart ideas for understanding diseases, which may soon be applied to ME/CFS.
Discuss the article on the Forums.

Overstimulation With Small Doses Of Methylation Support

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Tigger, Oct 12, 2016.

  1. Tigger

    Tigger

    Messages:
    66
    Likes:
    5
    Hi all,

    I'm not sure if this is the best place to post but I figured I'd give it a shot. I have had wonderful improvement through supporting methylation with a variety of supplements. However, even at low doses and careful balancing, anything that makes me feel truly better (better mood, more social, more energy, more endurance, etc.) comes at the cost of overstimulation, panic and sweating. Could this be as simple as histamine release in response to inflammation (need to take care of inflammation before supporting methylation)? Any help would be much appreciated. Thank you all.
     
  2. determined

    determined Senior Member

    Messages:
    303
    Likes:
    93
    USA: Deep South
    Tigger, for me, the methylation supplements (methylcobalamin and methyltetrahydrofolate) are incredibly powerful at almost homeopathic doses. In several years I've never increased my dose and believe they have helped me tremendously. For you, how low is "low?" Maybe it's too much for you.
     
  3. Tigger

    Tigger

    Messages:
    66
    Likes:
    5
    Hi. The best example is for a low dosage is one of these - Pure Encapsulations - Nutrient 950 without Iron. The ingredients are as follows:

    VALUES LISTED HERE ARE FOR 3 CAPSULES (AND I REACT FROM JUST ONE):
    -Vitamin A (as beta carotene)...7,500 IU
    -Vitamin C (as ascorbic acid)...500 mg
    -Vitamin D (as cholecalciferol) (D3)...400 Iu
    -Vitamin E (as d-alpha tocopherol succinate)...200 IU
    -Thiamin (as thiamin HCI) (B1)...50 mg
    -Riboflavin (as vitamin B2 and 28% riboflavin 5' phosphate (activated B2))...34.75 mg
    -Niacin (as niacinamide and 42% inositol hexaniacinate)...86 mg
    -Vitamin B6 (as pyridoxine HCI and 39% as pyridoxal 5' phosphate (activated B6))...20.5 mg
    -Folate (as Metafolin, L-5-MTHF)...400 mcg
    -Vitamin B12 (as methylcobalamin)...500 mcg
    -Biotin...400 mcg
    -Pantothenic acid (as calcium pantothenate) (B5)...200 mg
    -Calcium (as calcium citrate)...150 mg
    -Iodine (as potassium iodide)...100 mcg
    -Magnesium (as magnesium citrate)...100 mg
    -Zinc (as zinc picolinate)...12.5 mg
    -Selenium (as selenomethionine)...100 mcg
    -Copper (as copper glycinate)...1 mg
    -Manganese (as manganese aspartate)...2.5 mg
    -Chromium (as chromium polynicotinate)...100 mcg
    -Molybdenum (as molybdenum aspartate)...50 mcg
    -Potassium (as potassium aspartate)...49.5 mg
    -Boron (as boron glycinate)...1 mg
    -Vanadium (as vanadium asparate)...100 mcg
    -Proprietary mixed carotenoid blend (as lutein, lycopene, zeaxanthin)...425 mcg
     
  4. hixxy

    hixxy Senior Member

    Messages:
    1,111
    Likes:
    1,278
    Australia
    That's a lot for starting out if you're taking the full 3 capsules. Start on part of a capsule and titrate as tolerated.
     
  5. Tigger

    Tigger

    Messages:
    66
    Likes:
    5
    I'm actually only taking one capsule a day at the moment.
     
  6. Cheesus

    Cheesus Senior Member

    Messages:
    1,186
    Likes:
    5,084
    UK
    I don't have anything constructive to say regarding your stimulation dilemma, however I would like to note that you should be taking sublingual b12.

    Also, with so many different things in the supplement, it is possible that either the stimulation and/or improvemwnt has nothing to do with methylation or any of the B bitamins at all.
     
    PeterPositive likes this.
  7. caledonia

    caledonia

    Messages:
    4,203
    Likes:
    3,220
    Cincinnati, OH, USA
    I second what the others have said. Low is under 50mcg. Some people have trouble with even that.

    I'm doing 20mcg B12 and much less folate.

    The multi has many ingredients - hard to tell which ones are stimulating, although the B vitamins are the most notorious for that.

    And the B12 is not sublingual so it barely absorbs. It could cause methyl trapping over time.
     
    PeterPositive likes this.
  8. Tigger

    Tigger

    Messages:
    66
    Likes:
    5
    I should have clarified that I take sublingual methylcobalamin along with the Nutrient 950 capsule.

    @caledonia, are you just breaking crumbs off of the tablets and assuming it's roughly 20 mcg?

    Also, I've taken much larger amounts of just methylfolate and mb12 before without these issues but also without so many positive effects. I'm assuming taking all these nutrients together, even at relatively low doses, causes too much synergy, and hence, overstimulation and related negative symptoms. It is very frustrating trying to pinpoint the appropriate dosages and necessary cofactors.
     
  9. caledonia

    caledonia

    Messages:
    4,203
    Likes:
    3,220
    Cincinnati, OH, USA
    I'm using liquid methylcobalamin and have it diluted so that one drop equals 1mcg. See my doc Start Low and Go Slow in my signature link.
     

See more popular forum discussions.

Share This Page