I was curious about the relationship between overmethylation and Tryptophan. If one were overproducing Sam-e and lacking the appropriate cofactors to break this down to SAH, would this possibly put more emphasis on Tryptophans Kynurenine pathway to increase the levels of Niacin being manufactured in order to break down excess Sam-e? If this happened, would Serotonin and Melatonin be impaired? Also on a side note, does anyone have an idea why Melatonin would give someone who never experiences panic attacks guaranteed panic attacks every time? I never used to get them from melatonin, but as I've become more ill any time I take melatonin I have a pretty serious panic attack.