I'm fairly confused. I have read @Freddd say that it isnt overmethylation and is just paradoxical folate deficiency and or potassium deficiency. And also that folinic acid causes blockage of methylfolate. I have tried 400mcg metafolin + 1mg hydrox and it makes me wired and destroys my sleep (however helps my heart problems a lot) after a few days I stopped this and replaced with folinic acid 800mcg and my sleep is much better. What have people done to get rid of overmethylation? I have taken niacin in doses of grams across the course of day and night without lasting help. Anyone had success with B6/B2/GABA for overmethylation? Thanks!